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It is generally acknowledged that the mobility of protein atoms and the mobility of water molecules in the solvation layer are connected. In this article, we answer the question whether a similar interdependence exists between the motions of atoms of proteins separated by the hydration layers of variable thickness. The system consisted of a kinesin catalytic domain and a tubulin dimer. It was studied using molecular dynamics simulations. The analyzed atoms were located at the two distant protein surfaces that were facing each other. We demonstrated that the low-frequency (ca. 2 THz and less) collective movements of these two separate sets of atoms are to some extent interdependent. Based on this finding, it can be inferred that the low frequency large-scale internal motions of these proteins are also partially interdependent. The water-mediated protein–protein interactions, which are responsible for this interdependence, have a relatively long range of at least 2 nm at room temperature.
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- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
-
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
nr 17,
wydanie 10,
strony 6728 - 6733,
ISSN: 1463-9076 - Język:
- angielski
- Rok wydania:
- 2015
- Opis bibliograficzny:
- Kuffel A., Zielkiewicz J.: Water-mediated long-range interactions between the internal vibrations of remote proteins// PHYSICAL CHEMISTRY CHEMICAL PHYSICS. -Vol. 17, iss. 10 (2015), s.6728-6733
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/c5cp00090d
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 120 razy