Wyszukiwarka
Abstrakt
It is generally acknowledged that the mobility of protein atoms and the mobility of water molecules in the solvation layer are connected. In this article, we answer the question whether a similar interdependence exists between the motions of atoms of proteins separated by the hydration layers of variable thickness. The system consisted of a kinesin catalytic domain and a tubulin dimer. It was studied using molecular dynamics simulations. The analyzed atoms were located at the two distant protein surfaces that were facing each other. We demonstrated that the low-frequency (ca. 2 THz and less) collective movements of these two separate sets of atoms are to some extent interdependent. Based on this finding, it can be inferred that the low frequency large-scale internal motions of these proteins are also partially interdependent. The water-mediated protein–protein interactions, which are responsible for this interdependence, have a relatively long range of at least 2 nm at room temperature.
Cytowania
-
1 0
CrossRef
-
0
Web of Science
-
1 0
Scopus
Autorzy (2)
Cytuj jako
Pełna treść
pełna treść publikacji nie jest dostępna w portalu
Słowa kluczowe
Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
-
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
nr 17,
wydanie 10,
strony 6728 - 6733,
ISSN: 1463-9076 - Język:
- angielski
- Rok wydania:
- 2015
- Opis bibliograficzny:
- Kuffel A., Zielkiewicz J.: Water-mediated long-range interactions between the internal vibrations of remote proteins// PHYSICAL CHEMISTRY CHEMICAL PHYSICS. -Vol. 17, iss. 10 (2015), s.6728-6733
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/c5cp00090d
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 79 razy