Marlena Szeligowska - Publications - Bridge of Knowledge

Marlena Szeligowska

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Year 2017

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publication
- M. Misiak
- M. Heldt
- M. Szeligowska
- S. Mazzini
- L. Scaglioni
- G. J. Grabe
- M. Serocki
- J. J. Lica
- M. Świtalska
- J. Wietrzyk... and 6 others
- Oncotarget - Year 2017
nthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...

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