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Abstract
We have developed convenient methods for the synthesis of functionalized unsymmetrical dialkyl disulfides under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives 1 with functionalized alkyl thiolate anions, generated in situ from thioacetates2and sodium methoxide or butylamine. The developed method allows the preparation of unsymmetrical disulfides bearing additional hydroxy, carboxy, amino, azido, biotin, or maleimide functionalities
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.tetlet.2013.10.056
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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TETRAHEDRON LETTERS
no. 54,
edition 51,
pages 7021 - 7023,
ISSN: 0040-4039 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Lach S., Demkowicz S., Witt D.: An efficient and convenient synthesis of unsymmetrical disulfides from thioacetates// TETRAHEDRON LETTERS. -Vol. 54, iss. 51 (2013), s.7021-7023
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.tetlet.2013.10.056
- Verified by:
- Gdańsk University of Technology
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