Evaluation of the photoprotective effect of β-cyclodextrin on the emission of volatile degradation products of ranitidine - Publication - Bridge of Knowledge

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Evaluation of the photoprotective effect of β-cyclodextrin on the emission of volatile degradation products of ranitidine

Abstract

The process of the photo-excitation of ranitidine hydrochloride (RAN) in a solid state makes visible changes to its colour and generates an unpleasant odour. The purpose of the present study was to observe the protective effects of ˇ-cyclodextrin (CD) complexation as well as the effect of the mixture of two stoichiometries 1:1 and 1:2 (RAN:CD, IC) on the photostability of samples in a solid state. Samples of inclusion complexes (IC) and physical mixtures (PM) were prepared and irradiated for 48 h in a Suntest CPS+ chamber. Irradiated samples were analyzed using nuclear magnetic resonance (1H NMR), infrared spectroscopy (FT-IR), the differential scanning calorimetry method (DSC) and thermogravimetry analysis (TGA). Volatiles were monitored with the use of headspace-solid phase microextraction-gas
chromatography–mass spectrometry (HS-SPME-GC–MS). The protective effect of CD was noticed with respect to IC, and also PM. Achieved photostabilization of complexed RAN against photodegradation could be explained due to either the inclusion of the furan part of RAN into the CD cavity as shown by the 1H NMR ROESY (rotation frame nuclear Overhauser effect spectroscopy) spectrum or the screening effect of CD. FT-IR spectra, DSC curves and microscope images of irradiated samples of protected RAN did not indicate any physical changes, such as phase transfer.

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Details

Category:
Magazine publication
Type:
Magazine publication
Published in:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS no. 98, pages 113 - 119,
ISSN: 0731-7085
Publication year:
2014
DOI:
Digital Object Identifier (open in new tab) http://dx.doi.org/10.1016/j.jpba.2014.05.014
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