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Evaluation of the photoprotective effect of ˇ-cyclodextrin on the emission of volatile degradation products of ranitidine
Abstract
The process of the photo-excitation of ranitidine hydrochloride (RAN) in a solid state makes visible changes to its colour and generates an unpleasant odour. The purpose of the present study was to observe the protective effects of ˇ-cyclodextrin (CD) complexation as well as the effect of the mixture of two stoichiometries 1:1 and 1:2 (RAN:CD, IC) on the photostability of samples in a solid state. Sam- ples of inclusion complexes (IC) and physical mixtures (PM) were prepared and irradiated for 48 h in a Suntest CPS+ chamber. Irradiated samples were analyzed using nuclear magnetic resonance (1H NMR), infrared spectroscopy (FT-IR), the differential scanning calorimetry method (DSC) and thermogravime- try analysis (TGA). Volatiles were monitored with the use of headspace-solid phase microextraction-gas chromatography–mass spectrometry (HS-SPME-GC–MS). The protective effect of CD was noticed with respect to IC, and also PM. Achieved photostabilization of complexed RAN against photodegradation could be explained due to either the inclusion of the furan part of RAN into the CD cavity as shown by the 1H NMR ROESY (rotation frame nuclear Overhauser effect spectroscopy) spectrum or the screening effect of CD. FT-IR spectra, DSC curves and microscope images of irradiated samples of protected RAN did not indicate any physical changes, such as phase transfer.
Authors (3)
-
Marzena Jamrógiewicz
- Faculty of Pharmacy with the Subfaculty of Laboratory Medicine, Medical University of Gdansk Department of Physical Chemistry
-
Bartosz Wielgomas
- .. ..
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.jpba.2014.05.014
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
no. 98,
pages 113 - 119,
ISSN: 0731-7085 - Language:
- English
- Publication year:
- 2014
- Bibliographic description:
- Jamrógiewicz M., Wielgomas B., Strankowski M.: Evaluation of the photoprotective effect of ˇ-cyclodextrin on the emission of volatile degradation products of ranitidine// JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. -Vol. 98, (2014), s.113-119
- Verified by:
- Gdańsk University of Technology
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