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Improvement of opipramol base solubility by complexation with β-cyclodextrin

Abstract

Opipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio. Studies on the formation of inclusion complexes were carried out both in solution and in the solid state. The formation and physicochemical characterisation of the complexes were determined by UV spectroscopic measurement (UV–vis), Fourier Transform Infrared (FTIR) Spectroscopy, 1H Nuclear Magnetic Resonance (1H NMR, 2D NOESY NMR), thermoanalytical methods (TGA – Termogravimetric analysis, DSC – differential scanning calorimetry), X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The phase solubility profile with β-CD was classified as the AN- type, indicating the formation of the inclusion complex with a drug.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
SUPRAMOLECULAR CHEMISTRY no. 30, pages 1 - 12,
ISSN: 1061-0278
Language:
English
Publication year:
2018
Bibliographic description:
Majewska K., Skwierawska A., Kamińska B., Prześniak-Welenc M.: Improvement of opipramol base solubility by complexation with β-cyclodextrin// SUPRAMOLECULAR CHEMISTRY. -Vol. 30, nr. 1 (2018), s.1-12
DOI:
Digital Object Identifier (open in new tab) 10.1080/10610278.2017.1350677
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