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Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
Abstract
Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite® 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).
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Authors (7)
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Marta Miotke
- Uniwersytet Gdański, Wydział Matematyki, Fizyki i Informatyki Instytut Fizyki Doświadczalnej
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Justyna Strankowska
- Uniwersytet Gdański, Wydział Matematyki, Fizyki i Informatyki Instytut Fizyki Doświadczalnej
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Jerzy Kwela
- Uniwersytet Gdański, Wydział Matematyki, Fizyki i Informatyki Instytut Fizyki Doświadczalnej
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Marek Józefowicz
- Uniwersytet Gdański, Wydział Matematyki, Fizyki i Informatyki Instytut Fizyki Doświadczalnej
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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European Physical Journal Plus
no. 132,
pages 1 - 15,
ISSN: 2190-5444 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Miotke M., Strankowska J., Kwela J., Strankowski M., Piszczyk Ł., Józefowicz M., Gazda M.: Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels// European Physical Journal Plus. -Vol. 132, nr. 401 (2017), s.1-15
- DOI:
- Digital Object Identifier (open in new tab) 10.1140/epjp/i2017-11708-1
- Verified by:
- Gdańsk University of Technology
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