Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes

Justyna Strankowska; Małgorzata Grzywińska; Ewelina Łęgowska; Marek Józefowicz; Michał Strankowski

doi:10.3390/ma17010040

Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes

Abstract

This article describes the swelling and release mechanisms of paracetamol in polyurethane nanocomposite hydrogels containing Cloisite® 30B (organically modified montmorillonite). The transport mechanism, swelling and release processes of the active substance in nanocomposite matrix were studied using gravimetric and UV-Vis spectroscopic methods. Swelling and release processes depend on the amount of clay nanoparticles in these systems and the degree of crosslinking of PU/PEG/Cloisite® 30B hydrogel nanocomposites.

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Authors (5)

Justyna Strankowska
- Institute of Experimental Physics, Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland
Małgorzata Grzywińska mgr
- Neuroinformatics and Artificial Intelligence Lab, Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland
Ewelina Łęgowska mgr
- Academia Copernicana Interdisciplinary Doctoral School, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland
Marek Józefowicz
- Institute of Experimental Physics, Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland
Michał Strankowski dr hab. inż.

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Category:

Articles

Type:

artykuły w czasopismach

Published in:

Materials no. 17,
ISSN: 1996-1944

Language:

English

Publication year:

2024

Bibliographic description:

Strankowska J., Grzywińska M., Łęgowska E., Józefowicz M., Strankowski M.: Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes// Materials -,iss. 17/40 (2023),

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