Natural carbon-based quantum dots and their applications in drug delivery: A review

Akhila Nair; Józef Tadeusz Haponiuk; Sabu Thomas; Sreeraj Gopi

doi:10.1016/j.biopha.2020.110834

Natural carbon-based quantum dots and their applications in drug delivery: A review

Abstract

Natural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl, etc., provides improved quantum yield, physicochemical and optical properties which promote bioimaging, sensing, and drug delivery. This review provides comprehensive knowledge about NCDs for drug delivery applications by outlining the source and rationale behind NCDs, different routes of synthesis of NCDs and the merits of adopting each method. Detailed information regarding the mechanism behind the optical properties, toxicological profile including biosafety and biodistribution of NCDs that are favourable for drug delivery are discussed. The drug delivery applications of NCDs particularly as sensing and real-time tracing probe, antimicrobial, anticancer, neurodegenerative agents are reviewed. The clinical aspects of NCDs are also reviewed as an initiative to strengthen the case of NCDs as potent drug delivery agents.

Citations

1 8 9

CrossRef
0

Web of Science
1 8 6

Scopus

Authors (4)

Akhila Nair mgr
Józef Tadeusz Haponiuk (formerly: Józef Haponiuk) prof. dr hab. inż.
Sabu Thomas Profesor
Sreeraj Gopi

Cite as

Full text

download paper

downloaded 452 times

Publication version: Accepted or Published Version
License: open in new tab

Keywords

Details

Category:: Articles
Type:: artykuły w czasopismach
Published in:: BIOMEDICINE & PHARMACOTHERAPY no. 132,
ISSN: 0753-3322
Language:: English
Publication year:: 2020
Bibliographic description:: Nair A., Haponiuk J., Thomas S., Gopi S.: Natural carbon-based quantum dots and their applications in drug delivery: A review// BIOMEDICINE & PHARMACOTHERAPY -Vol. 132, (2020), s.110834-
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.biopha.2020.110834
Verified by:: Gdańsk University of Technology