Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition - Publication - Bridge of Knowledge

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Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition

Abstract

The skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related to bone fractures increases year by year. Nowadays, the regeneration of the bone tissue is performed by using autografts or allografts, but this treatment method possesses a few disadvantages. Therefore, new and promising methods of bone tissue regeneration are constantly being sought. They often include the implantation of tissue scaffolds, which exhibit proper mechanical and osteoconductive properties. In this paper, the preparation of polyurethane (PUR) scaffolds modified by gelatin as the reinforcing factor and hydroxyapatite as the bioactive agent was described. The unmodified and modified scaffolds were tested for their mechanical properties; morphological assessments using optical microscopy were also conducted, as was the ability for calcification using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Moreover, each type of scaffold was subjected to a degradation process in 5M NaOH and 2M HCl aqueous solutions. It was noticed that the best properties promoting the calcium phosphate deposition were obtained for scaffolds modified with 2% gelatin solution containing 5% of hydroxyapatite

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Polymers no. 12, pages 1 - 18,
ISSN: 2073-4360
Language:
English
Publication year:
2020
Bibliographic description:
Carayon I., Szarlej P., Łapiński M., Kucińska-Lipka J.: Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition// Polymers -Vol. 12,iss. 2 (2020), s.1-18
DOI:
Digital Object Identifier (open in new tab) 10.3390/polym12020410
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  46. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). open in new tab
Sources of funding:
  • Politechnika Gdańska nr. projektu 033206
Verified by:
Gdańsk University of Technology

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