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Abstract
The idea that synchronous neural activity underlies cognition has driven an extensive body of research in human and animal neuroscience. Yet, insufficient data on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-brain setting. Through the lens of memory encoding and retrieval processes, we construct whole-brain connectivity maps of fast gamma (30-100 Hz) and slow theta (3-8 Hz) spectral neural activity, based on data from 294 neurosurgical patients fitted with indwelling electrodes. Here we report that gamma networks desynchronize and theta networks synchronize during encoding and retrieval. Furthermore, for nearly all brain regions we studied, gamma power rises as that region desynchronizes with gamma activity elsewhere in the brain, establishing gamma as a largely asynchronous phenomenon. The abundant phenomenon of theta synchrony is positively correlated with a brain region's gamma power, suggesting a predominant low-frequency mechanism for inter-regional communication.
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Authors (15)
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E.a. Solomon
- University of Pennsylvania Department of Bioengineering
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J.e. Kragiel
- University of Pennsylvania Department of Psychology
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Michael R. Sperling
- Thomas Jefferson University Hospital Department of Neurology
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Ashwini Sharan
- Thomas Jefferson University Hospital Department of Neurosurgery
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Gregory Worrell
- Mayo Clinic Department of Neurology
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Cory S. Inman
- Emory School of Medicine Department of Neurosurgery
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Bradley Lega
- University of Texas Southwestern Department of Neurosurgery
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Kathryn A. Davis
- Hospital of the University of Pennsylvania Department of Neurology
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Joel M. Stein
- Hospital of the University of Pennsylvania Department of Radiology
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Barbara C. Jobst
- Dartmouth Medical Center Department of Neurology
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Kareem Zaghloul
- National Institutes of Health Surgical Neurology Branch
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Sameer A. Sheth
- Columbia University Medical Center Department of Neurosurgery
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Daniel S. Rizzuto
- University of Pennsylvania Department of Psychology
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Michael J. Kahana
- University of Pennsylvania Department of Psychology
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41467-017-01763-2
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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Nature Communications
no. 8,
edition 1,
ISSN: 2041-1723 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Solomon E., Kragiel J., Sperling M., Sharan A., Worrell G., Kucewicz M., Inman C., Lega B., Davis K., Stein J., Jobst B., Zaghloul K., Sheth S., Rizzuto D., Kahana M.: Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition// Nature Communications. -Vol. 8, iss. 1 (2017), s.-
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41467-017-01763-2
- Verified by:
- Gdańsk University of Technology
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