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Search results for: disulfides
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Katedry Chemii Organicznej
Research PotentialSynteza nowych związków organicznych w szczególności posiadających aktywność biologiczną. Opracowywanie i sprawdzanie w praktyce nowych metod syntezy związków organicznych. Inżynieria kryształów oraz zastosowanie dichroizmu kołowego. Badanie czynności optycznej związków konfiguracyjnie labilnych.
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Search results for: disulfides
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A novel and efficient synthesis of unsymmetrical disulfides
PublicationOpracowano metodę otrzymywania niesymetrycznych disulfidów z odpowiednich tioli w oparciu o bromek sulfenylowy.
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A versatile and convenient preparation of unsymmetrical diaryl disulfides
PublicationWe have developed a convenient method for the synthesis of unsymmetrical diaryl disulfides under mild conditions in excellent yields. The described method is based on the straightforward preparation of 5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinane-2-sulfenyl bromide from readily available 5,5-dimethyl-2-thiolo-2-thioxo-1,3,2-dioxaphosphorinane or bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl) disulfide. The unsymmetrical...
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An efficient and convenient synthesis of unsymmetrical disulfides from thioacetates
PublicationWe have developed convenient methods for the synthesis of functionalized unsymmetrical dialkyl disulfides under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives 1 with functionalized alkyl thiolate anions, generated in situ from thioacetates2and sodium methoxide or butylamine. The developed method allows the preparation...
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Recent Developments in the Synthesis of Unsymmetrical Disulfanes (Disulfides). A Review
PublicationThe synthesis of unsymmetrical disulfanes is an important transformation in organic synthesis and medicinal chemistry. The current review is intended to summarize achievements in the synthesis of unsymmetrical disulfanes over the last decade (2004–2014).
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Diastereoselective Synthesis of Z‐Alkenyl Disulfides from α‐Thiophosphorylated Ketones and Thiosulfonates
PublicationWe developed a simple and efficient method for the synthesis of functionalized unsymmetrical Z‐alkenyl disulfides under mild conditions in moderate to good yields. The designed method is based on the reaction of α‐thiophosphorylated carbonyl compounds with thiotosylates in the presence of a base. The developed method allows the preparation of unsymmetrical Z‐alkenyl disulfides bearing additional hydroxy, carboxy, or ester functionalities