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Search results for: j-domain proteins

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Search results for: j-domain proteins

  • Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70

    Publication
    • O. Shrestha
    • R. Sharma
    • B. Tomiczek
    • W. Lee
    • M. Tonelli
    • G. Cornilescu
    • M. Stolarska
    • Ł. Nierzwicki
    • J. Czub
    • J. Markley... and 3 others

    - PLOS ONE - Year 2019

    The J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...

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  • Two-step mechanism of J-domain action in driving Hsp70 function

    Publication
    • B. Tomiczek
    • W. Delewski
    • Ł. Nierzwicki
    • M. Stolarska
    • I. Grochowina
    • B. Schilke
    • R. Dutkiewicz
    • M. A. Uzarska
    • S. Ciesielski
    • J. Czub... and 2 others

    - PLoS Computational Biology - Year 2020

    J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode of interaction between a J-domain and an Hsp70, the structural and dynamic consequences of J-domain action once bound and how Hsp70s...

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  • A J-lossless coprime factorisation approach to H control in delta domain

    Publication

    - AUTOMATICA - Year 2002

    Praca dotyczy sterowania wielowymiarowym obiektem dynamicznym czasu ciągłego opisanym dyskretnoczasowym modelem w przestrzeni stanu, przy założeniu, że wskaźnik jakości sterowania oparty jest na normie H-inf. Odpowiednie zadanie optymalizacji tego wskaźnika rozwiązuje się, stosując tak zwaną względnie pierwszą J-bezstratną faktoryzację modelu sterowanego. Pokazano, że synteza optymalnego sterownika, wymagająca rozwiązania dwóch...

  • Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein

    Publication
    • M. Jelen
    • I. Grochowina
    • A. Grabinska-Rogala
    • S. Ciesielski
    • K. Dabrowska
    • B. Tomiczek
    • Ł. Nierzwicki
    • W. Delewski
    • B. Schilke
    • J. Czub... and 4 others

    - JOURNAL OF MOLECULAR BIOLOGY - Year 2023

    Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis drives conformational changes in Hsp70 that stabilize substrate binding. However, because of the transient nature of substrate and JDP...

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  • Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment

    Publication
    • A. Kryshtafovych
    • J. Moult
    • W. M. Billings
    • D. Della Corte
    • K. Fidelis
    • S. Kwon
    • K. Olechnovič
    • C. Seok
    • Č. Venclovas
    • J. Won... and 79 others

    - PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS - Year 2021

    Critical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on...

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