Year 2018

• Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase

  Publication

  • A. S. Skwarecki
  • M. Schielmann
  • D. Martynow
  • M. Kawczyński
  • A. Wiśniewska
  • M. J. Milewska
  • S. Milewski

  - JOURNAL OF PEPTIDE SCIENCE - Year 2018

  The antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...

  Full text to download in external service

Year 2017

• Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides

  Publication

  • M. Schielmann
  • P. Szweda
  • K. M. Gucwa
  • M. Kawczyński
  • M. J. Milewska
  • D. Martynow
  • J. Morschhauser
  • S. Milewski

  - Frontiers in Microbiology - Year 2017

  (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...

  Full text available to download

Year 2015

• Peptydy penetrujące – rodzaje i mechanizmy przenikania przez błony komórkowe

  Publication

  • M. Kawczyński
  • J. Kreczko-Kurzawa
  • Z. Maćkiewicz

  - Wiadomości Chemiczne - Year 2015

  Peptydy penetrujące z pewnością są wyjątkową i ciekawą grupą związków peptydowych. Zostały odkryte ponad dwadzieścia lat temu, ale wiedza na ich temat wciąż jest rozbudowywana. Liczne badania nad mechanizmami ich przenikania do wnętrza komórek pozwalają zrozumieć jakie cechy strukturalne warunkują ich zdolność do penetracji komórek. Wiedza ta pozwala na projektowanie nowych, bardziej efektywnych peptydów penetrujących., które mogą...

Year 2013

• Cell-penetrating peptides – mechanism of transduction and synthesis – short review

  Publication

  • M. Kawczyński

  - Year 2013

  Potential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biophar-maceuticals. Among other things, CPPs are capable of trans-porting...

  Full text to download in external service