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Enzymes of the L-methionine biosynthetic pathway as novel molecular targets for antifungal chemotherapy
The project contains a proposal of interdisciplinary studies aimed at evaluation of molecular basis for rational design of antifungals targeting selected enzymes of the L-methionine biosynthetic pathway (MBP) in human pathogenic fungi. The main research hypothesis is that particular enzymes of the MBP could be exploited as molecular targets for antifungals
Details
- Financial Program Name:
- OPUS
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Agreement:
- UMO-2020/39/B/NZ7/01519 z dnia 2021-07-08
- Realisation period:
- 2021-07-08 - 2025-07-07
- Project manager:
- dr hab. inż. Iwona Gabriel
- Realised in:
- Department of Pharmaceutical Technology and Biochemistry
- External institutions
participating in project: -
- Instytut Chemii Bioorganicznej PAN Poznań (Poland)
- Project's value:
- 1 677 700.00 PLN
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
Papers associated with that project
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Catalog Projects
Year 2022
-
Antifungal Effect of Penicillamine Due to the Selective Targeting of L-Homoserine O-Acetyltransferase
PublicationDue to the apparent similarity of fungal and mammalian metabolic pathways, the number of established antifungal targets is low, and the identification of novel ones is highly desirable. The results of our studies, presented in this work, indicate that the fungal biosynthetic pathway of L-methionine, an amino acid essential for humans, seems to be an attractive perspective. The MET2 gene from Candida albicans encoding L-homoserine...
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