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A novel methodology for the enantiomeric resolution of methamphetamine, its precursors and intermediates by GC-MS
Abstract
Impurity profiling and classification of abused drugs using chiral analytical techniques is of particular interest and importance because of the additional information obtained from this approach. When these methods are applied to the synthesis of illicitly used substances, they can supply valuable information about the conditions/chemicals used in the synthesis. In this study, simultaneous chiral separation of methylamphetamine, its common precursors and intermediates using gas chromatography-mass spectrometry (GC-MS) was carried out using fluorinated acid anhydrides as chemical derivatization reagents prior to gas chromatographic analysis on a 2,6-di-O-pentyl-3-propionyl silyl-γ-cyclodextrin stationary phase (CHIRALDEX G-PN). The method is able to separate all 10 enantiomers of interest with good qualitative precision under condition of repeatability and reproducibility. Detection by MS allows for the identity of analytes to be confirmed in the single analysis which is of particular interest to the forensic analysis.
Authors (3)
-
Calum Morrison
- School of Science Faculty of Science and Technology
Cite as
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Keywords
Details
- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Title of issue:
- Proceedings of the 9th International Students Conference "Modern Analytical Chemistry" strony 37 - 40
- Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Płotka J., Morrison C., Biziuk M.: A novel methodology for the enantiomeric resolution of methamphetamine, its precursors and intermediates by GC-MS// Proceedings of the 9th International Students Conference "Modern Analytical Chemistry"/ ed. K. Nesmerak Praga: University of Prague, Faculty of Science, 2013, s.37-40
- Verified by:
- Gdańsk University of Technology
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