Abstract
Borelioza jest najczęstszą chorobą odkleszczową dotykającą mieszkańców półkuli północnej. Chorobę tę wywołują bakterie zakwalifikowane do grupy Borrelia burgdorferi sensu lato. Współcześnie podstawą diagnostyki laboratoryjnej boreliozy jest dwustopniowe badanie serologiczne. Pierwszym etapem jest test immunoenzymatyczny (ELISA), jeżeli wynik badania jest dodatni lub wątpliwy jako test potwierdzający stosuje się technikę Western blot. W obu metodach jako główne źródło antygenów wykorzystuje się całkowite lizaty komórkowe B. burgdorferi s.l. Jednak ogromna różnorodność gatunków w obrębie B. burgdorferi s.l. oraz niski stopień zakonserwowania sekwencji ich białek sprawia, że wykorzystanie lizatów komórkowych jednego z genogatunków nie jest wystarczające do prawidłowego rozpoznania boreliozy. Liczne doniesienia literaturowe wykazują, że wykorzystanie antygenów rekombinantowych lub chimerycznych B. burgdorferi s.l. może być potencjalnym rozwiązaniem problemów występujących w immunodiagnostyce boreliozy. Jednak, aby testy diagnostyczne oparte na białkach rekombinantowych miały jak największą skuteczność należy wykorzystać w nich starannie wyselekcjonowane antygeny lub ich fragmenty. Dzięki takiemu podejściu można opracować test, którego czułość pozostanie niezależna od genogatunku B. burgdorferi s.l., który wywołał chorobę. Dodatkowo wykorzystanie jedynie fragmentów białek może zdecydowanie ograniczyć częstość występowania reakcji krzyżowych.
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- artykuły w czasopismach
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Postępy Mikrobiologii
no. 58,
pages 399 - 413,
ISSN: 0079-4252 - Language:
- Polish
- Publication year:
- 2019
- Bibliographic description:
- Grąźlewska W., Holec-Gąsior L.: ANTYGENY REKOMBINANTOWE W DIAGNOSTYCE SEROLOGICZNEJ BORELIOZY// Postępy Mikrobiologii -Vol. 58,iss. 4 (2019), s.399-413
- DOI:
- Digital Object Identifier (open in new tab) 10.21307/pm-2019.58.4.399
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