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Customizing nano-chitosan for sustainable drug delivery

Abstract

Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF CONTROLLED RELEASE no. 350, pages 175 - 192,
ISSN: 0168-3659
Language:
English
Publication year:
2022
Bibliographic description:
Saeedi M., Vahidi O., Moghbeli M. R., Ahmadi S., Asadnia M., Akhavan O., Seidi F., Rabiee M., Saeb M., Webster T. J., Varma R. S., Sharifi E., Zarrabi A., Rabiee N.: Customizing nano-chitosan for sustainable drug delivery// JOURNAL OF CONTROLLED RELEASE -Vol. 350, (2022), s.175-192
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.jconrel.2022.07.038
Sources of funding:
  • COST_FREE
Verified by:
Gdańsk University of Technology

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