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Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles
Abstract
Halogenated uracil derivatives are of great interest in modern cancer therapy, either as chemotherapeutics or radiosensitisers depending on their halogen atom. This work applies UV-Vis spectroscopy to study the radiation damage of uracil, 5-bromouracil and 5- uorouracil dissolved in water in the presence of gold nanoparticles upon irradiation with an Nd:YAG ns-pulsed laser operating at 532nm at dierent uences. Gold nanoparticles absorb light eciently by their surface plasmon resonance and can signicantly damage DNA in their vicinity by an increase of temperature and the generation of reactive secondary species, notably radical fragments and low energy electrons. A recent study using the same experimental approach characterized the ecient laser-induced decomposition of the pyrimidine ring structure of 5-bromouracil mediated by the surface plasmon resonance of gold nanoparticles. The present results show that the presence of irradiated gold nanoparticles decomposes the ring structure of uracil and its halogenated derivatives with similar eciency. In addition to the fragmentation of the pyrimidine ring, for 5-bromouracil the cleavage of the carbon-halogen bond could be observed, whereas for 5- uorouracil this reaction channel was inhibited. Locally-released halogen atoms can react with molecular groups within DNA, hence this result indicates a specic mechanism by which doping with 5-bromouracil can enhance DNA damage in the proximity of laser irradiated gold nanoparticles.
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Authors (7)
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Telma S. Marques
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Robin Schürmann
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Ilko Bald
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Maria Raposo
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Samuel Eden
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Nigel J. Mason
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1140/epjd/e2020-10208-3
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
EUROPEAN PHYSICAL JOURNAL D
no. 74,
pages 1 - 9,
ISSN: 1434-6060 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Marques T., Śmiałek-Telega M., Schürmann R., Bald I., Raposo M., Eden S., Mason N.: Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles// EUROPEAN PHYSICAL JOURNAL D -Vol. 74,iss. 11 (2020), s.1-9
- DOI:
- Digital Object Identifier (open in new tab) 10.1140/epjd/e2020-10208-3
- Verified by:
- Gdańsk University of Technology
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