Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state

Marzena Jamrógiewicz; Bartosz Wielgomas

doi:https://doi.org/10.1016/j.jpba.2012.12.019

Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state

Abstract

Ranitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state and in a solution, which creates manufacturing problems, requires appropriate storage conditions, and results in a short drug shelf-life. The aim of this work was to study the emission of volatile degradation products generated during photoexposition of ranitidine hydrochloride in a solid state. Significant changes in volatile profile ofirradiated RAN were detected using HS-SPME–GC–MS. Sixteen major peaks were noticed on the chromatograms of irradiated ranitidine and the structures of some compounds were elucidated, while the presence of acetaldoxime, thiazole, dimethylformamide, dimethylacetamide and 5-methylfurfural was confirmed by
means of the analysis of the authentic standards.