Direct brain stimulation modulates encoding states and memory performance in humans - Publication - MOST Wiedzy

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Direct brain stimulation modulates encoding states and memory performance in humans

Abstract

People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning. Stimulation increased encoding-state estimates and recall if delivered when the classifier indicated low encoding efficiency but had the reverse effect if stimulation was delivered when the classifier indicated high encoding efficiency. Higher encoding-state estimates from stimulation were associated with greater evidence of neural activity linked to contextual memory encoding. In identifying the conditions under which stimulation modulates memory, the data suggest strategies for therapeutically treating memory dysfunction.

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Authors (26)

  • Photo of  Youssef Ezzyat

    Youssef Ezzyat

  • Photo of  James E. Kragel

    James E. Kragel

  • Photo of  John F. Burke

    John F. Burke

  • Photo of  Deborah F. Levy

    Deborah F. Levy

  • Photo of  Anastasia Lyalenko

    Anastasia Lyalenko

  • Photo of  Paul Wanda

    Paul Wanda

  • Photo of  Logan O'Sullivan

    Logan O'sullivan

  • Photo of  Katherine B. Hurley

    Katherine B. Hurley

  • Photo of  Stanislav Busygin

    Stanislav Busygin

  • Photo of  Isaac Pedisich

    Isaac Pedisich

  • Photo of  Michael R. Sperling

    Michael R. Sperling

  • Photo of  Gregory Worrell

    Gregory Worrell

  • Photo of dr Michał Tomasz Kucewicz

    Michał Tomasz Kucewicz dr

    • Mayo Clinic, Rochester Department of Neurology
  • Photo of  Kathryn A. Davis

    Kathryn A. Davis

  • Photo of  Timothy H. Lucas

    Timothy H. Lucas

  • Photo of  Cory S. Inman

    Cory S. Inman

  • Photo of  Bradley C. Lega

    Bradley C. Lega

  • Photo of  Barbara C. Jobst

    Barbara C. Jobst

  • Photo of  Sameer A. Sheth

    Sameer A. Sheth

  • Photo of  Kareem Zaghloul

    Kareem Zaghloul

  • Photo of  Michael J. Jutras

    Michael J. Jutras

  • Photo of  Joel M. Stein

    Joel M. Stein

  • Photo of  Sandhitsu R. Das

    Sandhitsu R. Das

  • Photo of  Richard Gorniak

    Richard Gorniak

  • Photo of  Daniel S. Rizzuto

    Daniel S. Rizzuto

  • Photo of  Michael J. Kahana

    Michael J. Kahana

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
CURRENT BIOLOGY no. 27, edition 9, pages 1251 - 1258,
ISSN: 0960-9822
Language:
English
Publication year:
2017
Bibliographic description:
Ezzyat Y., Kragel J., Burke J., Levy D., Lyalenko A., Wanda P., O'sullivan L., Hurley K., Busygin S., Pedisich I., Sperling M., Worrell G., Kucewicz M., Davis K., Lucas T., Inman C., Lega B., Jobst B., Sheth S., Zaghloul K., Jutras M., Stein J., Das S., Gorniak R., Rizzuto D., Kahana M.: Direct brain stimulation modulates encoding states and memory performance in humans// CURRENT BIOLOGY. -Vol. 27, iss. 9 (2017), s.1251-1258
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.cub.2017.03.028
Verified by:
Gdańsk University of Technology

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