Search
Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall
Abstract
Short-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. However, precisely which information is carried when, and by which neurons, remains unclear. Using population decoding of activity in rat medial prefrontal cortex (mPFC) and dorsal hippocampal CA1, we confirm that mPFC populations lead in maintaining sample information across delays of an operant nonmatch to sample task, despite individual neurons firing only transiently. During sample encoding, distinct mPFC subpopulations joined distributed CA1-mPFC cell assemblies hallmarked by 4–5 Hz rhythmic modulation; CA1-mPFC assemblies re-emerged during choice episodes but were not 4–5 Hz modulated. Delay-dependent errors arose when attenuated rhythmic assembly activity heralded collapse of sustained mPFC encoding. Our results map component processes of memory-guided decisions onto heterogeneous CA1-mPFC subpopulations and the dynamics of physiologically distinct, distributed cell assemblies.
Citations
-
1 8
CrossRef
-
0
Web of Science
-
1 4
Scopus
Authors (7)
-
Aleksander Domanski dr
-
Eleonora Russo dr
-
Mark D. Tricklebank
-
J. Emma Robinson prof.
-
Daniel Durstewitz Prof.
-
Matthew W. Jones
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.cub.2023.02.029
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
CURRENT BIOLOGY
no. 33,
pages 1220 - 1236,
ISSN: 0960-9822 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Domanski A., Kucewicz M., Russo E., Tricklebank M. D., Robinson J. E., Durstewitz D., Jones M. W.: Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall// CURRENT BIOLOGY -Vol. 33,iss. 7 (2023), s.1220-1236
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.cub.2023.02.029
- Sources of funding:
-
- Wellcome Trust UK
- Medical Research Council UK
- Verified by:
- Gdańsk University of Technology
seen 97 times
Recommended for you
Combined Single Neuron Unit Activity and Local Field Potential Oscillations in a Human Visual Recognition Memory Task
- M. T. Kucewicz,
- B. M. Berry,
- M. R. Bower
- + 4 authors
Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation.
- M. T. Kucewicz,
- M. D. Tricklebank,
- R. Bogacz
- + 1 authors
High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?
- M. Kucewicz,
- J. Garcia Salinas,
- J. Cimbalnik
- + 2 authors
Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
- Ç. Topçu,
- V. Marks,
- K. Saboo
- + 5 authors