Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates

Piotr Szweda; Katarzyna Magdalena Gucwa; Ewelina Kurzyk; Ewa Romanowska; Katarzyna Dzierżanowska-Fangrat; Anna Zielińska-Jurek; Piotr Kuś; Sławomir Milewski

doi:10.1007/s12088-014-0508-2

Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates

Abstract

Development of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among tested essential oils, the highest activity has definitely been found in the case of the oil isolated from the bark of Cinnamomum cassia, with MIC and MFC values for all tested strains in the range of 0.0006–0.0097 % (v/v) and 0.0012–0.019 % (v/v), respectively. High activity was also observed for the Lemon, Basil, Thyme, Geranium and Clove (from buds) essential oils. Significant differences in fungicidal activity have been observed in the case of four tested propolis samples. Only one of them revealed high activity, with MFC values in the range from 0.156 to 1.25 % (v/v). Satisfactory fungicidal activity, against C. albicans and C. glabrata isolates, was also observed in the case of silver nanoparticles, however C. krusei isolates were mostly resistant. We also revealed that constituents of most of essential oils and propolis as well as silver nanoparticles are not substrates for drug transporters, which belong to the most important factors affecting resistance of Candida spp. clinical isolates to many of conventional antimycotics. To conclude, the results of our investigation revealed that essential oils, propolis and silver nanoparticles represent high potential for controlling and prevention candidiasis.

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Authors (8)

Piotr Szweda dr hab. inż.
Katarzyna Magdalena Gucwa
Ewelina Kurzyk
Ewa Romanowska
- Centrum Zdrowia Dziecka w Warszawie Katedra Mikrobiologii Klinicznej i Immunologii
Katarzyna Dzierżanowska-Fangrat
- Centrum Zdrowia Dziecka w Warszawie Katedra Mikrobiologii Klinicznej i Immunologii
Anna Zielińska-Jurek prof. dr hab. inż.
Piotr Kuś
- Wroclaw Medical University Department of Pharmacognosy
Sławomir Milewski prof. dr hab. inż.

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Keywords

CANDIDA ALBICANS CANDIDA GLABRATA CANDIDA KRUSEI ESSENTIAL OILS PROPOLIS SILVER NANOPARTICLES INT

Details

Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: INDIAN JOURNAL OF MICROBIOLOGY no. 55, edition 2, pages 175 - 183,
ISSN: 0046-8991
Language:: English
Publication year:: 2015
Bibliographic description:: Szweda P., Gucwa K., Kurzyk E., Romanowska E., Dzierżanowska-Fangrat K., Zielińska-Jurek A., Kuś P., Milewski S.: Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates// INDIAN JOURNAL OF MICROBIOLOGY. -Vol. 55, iss. 2 (2015), s.175-183
DOI:: Digital Object Identifier (open in new tab) 10.1007/s12088-014-0508-2
Verified by:: Gdańsk University of Technology