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Abstract
The establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as "cellular consolidation" (Dudai and Morris, 2013). Reactivation of neural activity patterns during waking behaviors that occurs on a timescale of seconds to minutes is thought to constitute memory recall (O'Keefe and Nadel, 1978), whereas consolidation of memory traces may be revealed and served by correlated firing (reactivation) that appears during sleep under conditions suitable for synaptic modification (Buhry et al., 2011). Although reactivation has been observed in human neuronal recordings (Gelbard-Sagiv et al., 2008; Miller et al., 2013), reactivation during sleep has not, likely because data are difficult to obtain and the effect is subtle. Seizures, however, provide intense and synchronous, yet sparse activation (Bower et al., 2012) that could produce a stronger consolidation effect if seizures activate learning-related mechanisms similar to those activated by learned tasks. Continuous wide-bandwidth recordings from patients undergoing intracranial monitoring for drug-resistant epilepsy revealed reactivation of seizure-related neuronal activity during subsequent SWS, but not wakefulness. Those neuronal assemblies that were most strongly activated during seizures showed the largest correlation changes, suggesting that consolidation selectively strengthened neuronal circuits activated by seizures. These results suggest that seizures "hijack" physiological learning mechanisms and also suggest a novel epilepsy therapy targeting neuronal dynamics during post-seizure sleep.
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Authors (12)
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Mark R. Bower
- Department of Neurology
-
Matt Stead
- Department of Neurology
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Regina S. Bower
- Department of Neurologic Surgery
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Vladimir Sulc
- Department of Neurology
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Jan Cymbalnik
- Department of Neurology
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Benjamin H. Brinkmann
- Department of Neurology
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Vincent Vasoli
- Department of Neurology
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Erik K. ST.Louis
- Departments of Medicine and Neurology
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Frederic Meyer
- Department of Neurologic Surgery
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W. Richard Marsh
- Department of Neurologic Surgery
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Gregory A. Worrell
- Department of Neurology
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1523/JNEUROSCI.3019-14.2015
- License
- Copyright (2015 the authors)
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Journal of Neuroscience
no. 35,
edition 3,
pages 999 - 1010,
ISSN: 0270-6474 - Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Bower M., Stead M., Bower R., Kucewicz M., Sulc V., Cymbalnik J., Brinkmann B., Vasoli V., St.Louis E., Meyer F., Marsh W., Worrell G.: Evidence for consolidation of neuronal assemblies after seizures in humans// Journal of Neuroscience. -Vol. 35, iss. 3 (2015), s.999-1010
- DOI:
- Digital Object Identifier (open in new tab) 10.1523/jneurosci.3019-14.2015
- Verified by:
- Gdańsk University of Technology
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