FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD
Abstract
Small particles like pellets are coated in fluid bed systems. This method can be also feasible for minitablets but the selection of optimal process parameters is complicated. The aim of the research was to optimize the coating process for minitablets and to compare the conditions required for pellets. Minimum fluidization velocities (umf) for 2.0 and 2.5 mm minitablets and 0.7-0.8 mm or 1.0-1.25 mm pellets were determined experimentally. Additionally, the results were verified using the Ergun equation. The smallest relative differences between the calculated and experimental values of umf were obtained for P0.7 (4.6%), while the largest for MT2.5 (11.8%). To simplify optimization of the coating process, Design of Experiment (DoE) based on the Taguchi method was employed. Selection of the best process parameters was based on the film thickness measurements for minitablets, while the sieve analysis was used for pellets to detect agglomeration. The best combination of process parameters resulted in uniform film thickness in minitablets, with RSD less than 15%, and the pellets batch containing only 0.25% of bonded particles. It was found that the largest impact on the uniform film deposition on minitablets had a spraying pressure, responsible for the size of coating mixture droplets. In the case of pellets, the most critical was the inlet air temperature. The presented research demonstrated that it was possible to achieve the best parameters of the coating process for minitablets and pellets by combining calculations of minimum fluidization velocity and Design of Experiment based on the Taguchi method.
Citations
-
0
CrossRef
-
0
Web of Science
-
0
Scopus
Authors (4)
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
- open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Acta Poloniae Pharmaceutica - Drug Research
no. 77,
pages 161 - 173,
ISSN: 0001-6837 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Magdalena T., Kawalec-Pietrenko B., Sznitowska M., Rybarczyk P.: FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD// Acta Poloniae Pharmaceutica - Drug Research -Vol. 77,iss. 1 (2020), s.161-173
- DOI:
- Digital Object Identifier (open in new tab) 10.32383/appdr/113595
- Bibliography: test
-
- Davidson J.F., Harrison D.: Fluidization. p. 847, Academic Press, London 1971.
- Levenspiel O.: Engineering Flow and Heat Exchange. p. 366, Plenum Press, New York 1984. open in new tab
- Yang W.C.: Handbook of fluidization and fluid- particle systems, Marcel Dekker, New York 2003. open in new tab
- Gibilaro L.G.: Fluidization-dynamics?: The for- mulation and applications of a predictive theory for the fluidized state. p. 256, Butterworth- Heinemann, Oxford 2001. open in new tab
- Smith P.: Applications of Fluidization to Food Processing. p. 264, John Wiley & Sons, USA 2008. open in new tab
- Swarbrick J.: Encyclopaedia of Pharmaceutical Technology. p. 4372, Informa Healthcare 2007. open in new tab
- Behzadi S.S., Toegel S., Viernstein H.: Recent Pat. Drug Deliv. Formul. 2, 209 (2008). open in new tab
- Felton L.A., Porter S.C.: Expert Opi. Drug Deliv. 10, 421 (2013). open in new tab
- Huttlin H.: Apparatus for treating particulate material. US 2006/0112589 A1, 2006. open in new tab
- Cahyadi C., Koh J.J.S., Loh Z.H., Chan L.W., Heng P.W.S.: AAPS PharmSciTech. 13, 1276 (2012.) open in new tab
- Dehnad K.: Quality control, robust design and the Taguchi method. p. 323, Pacific Grove: Wadsworth & Brooks/Cole Advanced Books & Software 1989. open in new tab
- Ghica M.V., Popa L., ™aramet G., Leca M., Lupuliasa D., Moisescu ™.: Farmacia 59, 321 (2011).
- Kluk A., Sznitowska M.: åwiat Przem. Farm. 1, 22 (2012) (in Polish).
- Passos M.L., Barrozo M.A.S., Mujumdar A.S.: Fluidization Engineering. Practice. p. 276, Laval, Kanada 2013.
- Hartnett J.P., Irvine T.F.: Advances in Heat Transfer. p. 365, Academic Press, New York 1989.
- Liu B., Zhang X., Wang L., Hong H.: Particuology 6, 125 (2008). open in new tab
- Czajkowska M., Sznitowska M., Kleinebudde P.: Int. J. Pharm. 495, 347 (2015). open in new tab
- Verified by:
- Gdańsk University of Technology
seen 178 times