FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD - Publication - MOST Wiedzy

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FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD

Abstract

Small particles like pellets are coated in fluid bed systems. This method can be also feasible for minitablets but the selection of optimal process parameters is complicated. The aim of the research was to optimize the coating process for minitablets and to compare the conditions required for pellets. Minimum fluidization velocities (umf) for 2.0 and 2.5 mm minitablets and 0.7-0.8 mm or 1.0-1.25 mm pellets were determined experimentally. Additionally, the results were verified using the Ergun equation. The smallest relative differences between the calculated and experimental values of umf were obtained for P0.7 (4.6%), while the largest for MT2.5 (11.8%). To simplify optimization of the coating process, Design of Experiment (DoE) based on the Taguchi method was employed. Selection of the best process parameters was based on the film thickness measurements for minitablets, while the sieve analysis was used for pellets to detect agglomeration. The best combination of process parameters resulted in uniform film thickness in minitablets, with RSD less than 15%, and the pellets batch containing only 0.25% of bonded particles. It was found that the largest impact on the uniform film deposition on minitablets had a spraying pressure, responsible for the size of coating mixture droplets. In the case of pellets, the most critical was the inlet air temperature. The presented research demonstrated that it was possible to achieve the best parameters of the coating process for minitablets and pellets by combining calculations of minimum fluidization velocity and Design of Experiment based on the Taguchi method.

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Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Acta Poloniae Pharmaceutica - Drug Research no. 77, pages 161 - 173,
ISSN: 0001-6837
Language:
English
Publication year:
2020
Bibliographic description:
Magdalena T., Kawalec-Pietrenko B., Sznitowska M., Rybarczyk P.: FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD// Acta Poloniae Pharmaceutica - Drug Research -Vol. 77,iss. 1 (2020), s.161-173
DOI:
Digital Object Identifier (open in new tab) 10.32383/appdr/113594
Verified by:
Gdańsk University of Technology

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