Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients - Publication - Bridge of Knowledge

Your account

login

Search

Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients

Abstract

Gender differences in the burden of cardiovascular disease (CVD) have been observed worldwide. In this study, plasmatic levels of trimethylamine (TMA) and blood oxidative biomarkers have been evaluated in 358 men (89 controls and 269 CVD patients) and 189 women (64 control and 125 CVD patients). The fluorescence technique was applied to determine erythrocyte membrane fluidity using 1,6-diphenyl-1,3,5-hexatriene (DPH) and Laurdan, while lipid hydroperoxides were assessed by diphenyl − 1-pyrenylphosphine (DPPP). Results show that levels of plasmatic TMA were higher in healthy men with respect to healthy women (p = 0.0001). Significantly lower TMA was observed in male CVD patients (0.609 ± 0.104 μM) compared to healthy male controls (0.680 ± 0.118 μ M) ( p < 0.001), while higher levels of TMA were measured in female CVD patients (0.595 ± 0.115 μ M) with respect to female controls (0.529 ± .073 μ M) ( p < 0.001). DPPP was significantly higher in healthy control men than in women (p < 0.001). Male CVD patients displayed a lower value of DPPP (2777 ± 1924) compared to healthy controls (5528 ± 2222) ( p < 0.001), while no significant changes were measured in females with or without CVD (p > 0.05). Membrane fluidity was significantly higher ( p < 0.001) in the hydrophobic bilayer only in control male subjects. In conclusion, gender differences were observed in blood oxidative biomarkers, and DPPP value might be suggested as a biomarker predictive of CVD only in men.

Citations

  • 6

    CrossRef

  • 0

    Web of Science

  • 6

    Scopus

Authors (11)

Cite as

Full text

download paper
downloaded 65 times
Publication version
Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.3390/biomedicines8080238
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Biomedicines no. 8,
ISSN: 2227-9059
Language:
English
Publication year:
2020
Bibliographic description:
Bordoni L., Fedeli D., Piangerelli M., Pelikant-Malecka I., Radulska A., Samulak J., Sawicka A., Lewicki L., Kalinowski L., Olek R., Gabbianelli R.: Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients// Biomedicines -Vol. 8,iss. 8 (2020), s.238-
DOI:
Digital Object Identifier (open in new tab) 10.3390/biomedicines8080238
Verified by:
Gdańsk University of Technology

seen 107 times

Recommended for you

Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study

  • L. Bordoni,
  • J. J. Samulak,
  • A. K. Sawicka
  • + 6 authors
2020

Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria

2023

Selected adipocytokines in patients with an incidentally discovered pheochromocytoma

2020

CARDIOVASCULAR RISK FACTORS AMONG POLISH EMPLOYEES OF UNIFORMED SERVICES

  • B. G. Trzeciak,
  • W. Kowalczyk,
  • S. Grymek
  • + 2 authors
2023
Meta Tags