Search
Abstract
The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum.
Citations
-
5
CrossRef
-
0
Web of Science
-
6
Scopus
Authors (7)
-
Mikayel Ginovyan PhD
-
Pierre Andreoletti
-
Mustapha Cherkaoui-malki
-
Naira Sahakyan
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3934/biophy.2022024
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
AIMS Biophysics
no. 9,
pages 282 - 293,
ISSN: 2377-9098 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Ginovyan M., Bartoszek-Pączkowska A., Koss-Mikołajczyk I., Kusznierewicz B., Andreoletti P., Cherkaoui-malki M., Sahakyan N.: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract// AIMS Biophysics -Vol. 9,iss. 4 (2022), s.282-293
- DOI:
- Digital Object Identifier (open in new tab) 10.3934/biophy.2022024
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
seen 101 times
Recommended for you
The Action Mechanisms, Anti-Cancer and Antibiotic-Modulation Potential of Vaccinium myrtillus L. Extract
- M. Ginovyan,
- A. Babayan,
- A. Shirvanyan
- + 6 authors
Lepidium peruvianum as a Source of Compounds with Anticancer and Cosmetic Applications
- D. Kasprzak,
- K. Gaweł-Bęben,
- W. Kukuła-Koch
- + 12 authors
Phenolic compounds from Nerium oleander leaves: microwave assisted extraction, characterization, antiproliferative and cytotoxic activities
- S. Ayouaz,
- S. C. Oliveira-Alves,
- K. Lefsih
- + 6 authors
Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage
- A. Hudecova,
- B. Kusznierewicz,
- K. Hasplova
- + 5 authors