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Human memory enhancement through electrical stimulation in the temporal cortex

Abstract

Direct electrical stimulation of the human brain can elicit sensory and motor perceptions as well as recall of memories. Stimulating higher order association areas of the lateral temporal cortex in particular was reported to activate visual and auditory memory representations of past experiences (Penfield and Perot, 1963). We hypothesized that this effect could be used to modulate memory processing. Recent attempts at memory enhancement in the human brain have been focused on the hippocampus and other mesial temporal lobe structures, with a few reports of memory improvement in small studies of individual brain regions. Here, we investigated the effect of stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and temporal cortex. Intracranial electrode recordings with stimulation were used to assess verbal memory performance in a group of 22 patients (nine males). We show enhanced performance with electrical stimulation in the lateral temporal cortex (paired t-test, P = 0.0067), but not in the other brain regions tested. This selective enhancement was observed both on the group level, and for two of the four individual subjects stimulated in the temporal cortex. This study shows that electrical stimulation in specific brain areas can enhance verbal memory performance in humans.

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Authors (20)

  • Photo of dr Michał Tomasz Kucewicz

    Michał Tomasz Kucewicz dr

    • Mayo Clinic Departament of Neurology
  • Photo of  Brent M. Berry

    Brent M. Berry

    • Mayo Clinic Departament of Neurology
  • Photo of  Laura R. Miller

    Laura R. Miller

    • Mayo Clinic Departament of Neurology
  • Photo of  Fatemeh Khadjevand

    Fatemeh Khadjevand

    • Mayo Clinic Departament of Neurology
  • Photo of  Youssef Ezzyat

    Youssef Ezzyat

    • University of Pennsylvania Departament of Psychology
  • Photo of  Joel M. Stein

    Joel M. Stein

    • University of Pennsylvania Hospital Departament of Radiology
  • Photo of  Vaclav Kremen

    Vaclav Kremen

    • Mayo Clinic Departament of Neurology
  • Photo of  Benjamin H. Brinkmann

    Benjamin H. Brinkmann

    • Mayo Clinic Departament of Neurology
  • Photo of  Paul Wanda

    Paul Wanda

    • Departament of Radiology Departament of Psychology
  • Photo of  Michael R. Sperling

    Michael R. Sperling

    • Thomas Jefferson University Hospital Departament of Neurology
  • Photo of  Richard Gorniak

    Richard Gorniak

    • Thomas Jefferson University Hospital Departament of Radiology
  • Photo of  Kathryn A. Davis

    Kathryn A. Davis

    • University of Pennsylvania Hospital Departament of Neurology
  • Photo of  Barbara C. Jobst

    Barbara C. Jobst

    • Dortmouth-Hitchcock Medicinal Center Departament of Neurology
  • Photo of  Robert E. Gross

    Robert E. Gross

    • Emory University Departament of Neurosurgery
  • Photo of  Bradley Lega

    Bradley Lega

    • UT Southwestern Medicinal Center Departament of Neurosurgery
  • Photo of  Jamie Van Gompel

    Jamie Van Gompel

    • Mayo Clinic Departament of Neurosurgery
  • Photo of  Matt Stead

    Matt Stead

    • Departament of Neurosurgery Departament of Neurology
  • Photo of  Daniel S. Rizzuto

    Daniel S. Rizzuto

    • University of Pennsylvania Departament of Psychology
  • Photo of  Michael J. Kahana

    Michael J. Kahana

    • University of Pennsylvania Departament of Psychology
  • Photo of  Gregory A. Worrell

    Gregory A. Worrell

    • Mayo Clinic Departament of Neurology

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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Brain: A Journal of Neurology no. 141, edition 4, pages 971 - 978,
ISSN: 0006-8950
Language:
English
Publication year:
2018
Bibliographic description:
Kucewicz M., Berry B., Miller L., Khadjevand F., Ezzyat Y., Stein J., Kremen V., Brinkmann B., Wanda P., Sperling M., Gorniak R., Davis K., Jobst B., Gross R., Lega B., Gompel J., Stead M., Rizzuto D., Kahana M., Worrell G.: Human memory enhancement through electrical stimulation in the temporal cortex// Brain: A Journal of Neurology. -Vol. 141, iss. 4 (2018), s.971-978
DOI:
Digital Object Identifier (open in new tab) 10.1093/brain/awx373
Verified by:
Gdańsk University of Technology

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