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Abstract
Direct electrical stimulation of the human brain can elicit sensory and motor perceptions as well as recall of memories. Stimulating higher order association areas of the lateral temporal cortex in particular was reported to activate visual and auditory memory representations of past experiences (Penfield and Perot, 1963). We hypothesized that this effect could be used to modulate memory processing. Recent attempts at memory enhancement in the human brain have been focused on the hippocampus and other mesial temporal lobe structures, with a few reports of memory improvement in small studies of individual brain regions. Here, we investigated the effect of stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and temporal cortex. Intracranial electrode recordings with stimulation were used to assess verbal memory performance in a group of 22 patients (nine males). We show enhanced performance with electrical stimulation in the lateral temporal cortex (paired t-test, P = 0.0067), but not in the other brain regions tested. This selective enhancement was observed both on the group level, and for two of the four individual subjects stimulated in the temporal cortex. This study shows that electrical stimulation in specific brain areas can enhance verbal memory performance in humans.
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Authors (20)
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Brent M. Berry
- Mayo Clinic Departament of Neurology
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Laura R. Miller
- Mayo Clinic Departament of Neurology
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Fatemeh Khadjevand
- Mayo Clinic Departament of Neurology
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Youssef Ezzyat
- University of Pennsylvania Departament of Psychology
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Joel M. Stein
- University of Pennsylvania Hospital Departament of Radiology
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Vaclav Kremen
- Mayo Clinic Departament of Neurology
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Benjamin H. Brinkmann
- Mayo Clinic Departament of Neurology
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Paul Wanda
- Departament of Radiology Departament of Psychology
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Michael R. Sperling
- Thomas Jefferson University Hospital Departament of Neurology
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Richard Gorniak
- Thomas Jefferson University Hospital Departament of Radiology
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Kathryn A. Davis
- University of Pennsylvania Hospital Departament of Neurology
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Barbara C. Jobst
- Dortmouth-Hitchcock Medicinal Center Departament of Neurology
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Robert E. Gross
- Emory University Departament of Neurosurgery
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Bradley Lega
- UT Southwestern Medicinal Center Departament of Neurosurgery
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Jamie Van Gompel
- Mayo Clinic Departament of Neurosurgery
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Matt Stead
- Departament of Neurosurgery Departament of Neurology
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Daniel S. Rizzuto
- University of Pennsylvania Departament of Psychology
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Michael J. Kahana
- University of Pennsylvania Departament of Psychology
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Gregory A. Worrell
- Mayo Clinic Departament of Neurology
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1093/brain/awx373
- License
- Copyright (2018 Oxford University Press)
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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Brain: A Journal of Neurology
no. 141,
edition 4,
pages 971 - 978,
ISSN: 0006-8950 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Kucewicz M., Berry B., Miller L., Khadjevand F., Ezzyat Y., Stein J., Kremen V., Brinkmann B., Wanda P., Sperling M., Gorniak R., Davis K., Jobst B., Gross R., Lega B., Gompel J., Stead M., Rizzuto D., Kahana M., Worrell G.: Human memory enhancement through electrical stimulation in the temporal cortex// Brain: A Journal of Neurology. -Vol. 141, iss. 4 (2018), s.971-978
- DOI:
- Digital Object Identifier (open in new tab) 10.1093/brain/awx373
- Verified by:
- Gdańsk University of Technology
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