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Abstract
In this study, thin films based on hyaluronic acid (HA) with tannic acid (TA) were investigated in three different weight ratios (80HA/20TA, 50HA/50TA, 20HA/80TA) for their application as materials for wound healing. Surface free energy, as well as their roughness, mechanical properties, water vapor permeability rate, and antioxidant activity were determined. Moreover, their compatibility with blood and osteoblast cells was investigated. The irritation effect caused by hyaluronic acid/tannic acid films was also considered with the use of are constructed human epidermis model. The irritation effect for hyaluronic acid/tannic acid films by the in vitro method was also studied. The low surface free energy, surface roughness, and antioxidant activity presented by the obtained films were examined. All the tested compositions of hyaluronic acid/tannic acid films were hemocompatible, but only films based on 50HA/50TA were fully cytocompatible. Regarding the potential implantation, all the films except 80HA/20TA showed appropriate mechanical properties. The specimens did not exert the irritation effect during the studies involving reconstructed human epidermis.
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Authors (7)
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Marcin Małek dr inż.
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Anna Ronowska dr hab. n. med.
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Anna Michno dr hab. n. med.
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Anna Pałubicka dr
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Agnieszka Klimek
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Beata Kaczmarek-Szczepańska dr
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ijbiomac.2023.128101
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
no. 254,
ISSN: 0141-8130 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Wekwejt M., Małek M., Ronowska A., Michno A., Pałubicka A., Klimek A., Kaczmarek-Szczepańska B.: Hyaluronic acid/tannic acid films for wound healing application// INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES -Vol. 254,iss. part 3 (2024), s.128101-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ijbiomac.2023.128101
- Sources of funding:
-
- COST_FREE This research was funded by Nicolaus Copernicus University in Torun (grant number 282/2021 IDUB) (B.K.S.).
- Verified by:
- Gdańsk University of Technology
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