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Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis
Abstract
A fast and efficient method for the isolation of the C-glucosidated xanthones mangiferin and isomangiferin from the South-African plant Cyclopia genistoides was developed for the first time. Two benzophenone derivatives: 3-C-β-glucosides of maclurin and iriflophenone, were isolated from C. genistoides extracts using semi-preparative. The structures of the compounds were determined by 1D and 2D NMR experiments and/or LC-DAD-ESI–MS.
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Authors (8)
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Adam Kokotkiewicz
- Gdański Uniwersytet Medyczny Wydził Farmacji
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Maria Łuczkiewicz
- Gdański Uniwersytet Medyczny Wydział Farmacji, Katedra Farmakognozji
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Justyna Pawłowska
- Gdański Uniwersytet Medyczny Wydział Lekarski, Katedra Fizjopatologii.
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Piotr Łuczkiewicz
- Uniwersyteckie Centrum Kliniczne (GUMED) Oddział Ortopedii.
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Jacek Witkowski
- Gdański Uniwersytet Medyczny Katedra Fizjopatologii
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Ewa Bryl
- Gdański Uniwersytet Medyczny Wydział Lekarski, Katedra Fizjopatologii.
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Adam Buciński
- Uniwersytet Mikołaja Kopernika, Collegium Medicum Wydział Farmaceutyczny
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Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
FITOTERAPIA
no. 90,
pages 199 - 208,
ISSN: 0367-326X - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Kokotkiewicz A., Łuczkiewicz M., Pawłowska J., Łuczkiewicz P., Sowiński P., Witkowski J., Bryl E., Buciński A.: Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis// FITOTERAPIA. -Vol. 90, (2013), s.199-208
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.fitote.2013.07.020
- Verified by:
- Gdańsk University of Technology
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