Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis - Publication - Bridge of Knowledge

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Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis

Abstract

A fast and efficient method for the isolation of the C-glucosidated xanthones mangiferin and isomangiferin from the South-African plant Cyclopia genistoides was developed for the first time. Two benzophenone derivatives: 3-C-β-glucosides of maclurin and iriflophenone, were isolated from C. genistoides extracts using semi-preparative. The structures of the compounds were determined by 1D and 2D NMR experiments and/or LC-DAD-ESI–MS.

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Authors (8)

  • Photo of Adam Kokotkiewicz

    Adam Kokotkiewicz

    • Gdański Uniwersytet Medyczny Wydził Farmacji
  • Photo of Maria Łuczkiewicz

    Maria Łuczkiewicz

    • Gdański Uniwersytet Medyczny Wydział Farmacji, Katedra Farmakognozji
  • Photo of Justyna Pawłowska

    Justyna Pawłowska

    • Gdański Uniwersytet Medyczny Wydział Lekarski, Katedra Fizjopatologii.
  • Photo of Piotr Łuczkiewicz

    Piotr Łuczkiewicz

    • Uniwersyteckie Centrum Kliniczne (GUMED) Oddział Ortopedii.
  • Photo of dr inż. Paweł Sowiński

    Paweł Sowiński dr inż.

  • Photo of Jacek Witkowski

    Jacek Witkowski

    • Gdański Uniwersytet Medyczny Katedra Fizjopatologii
  • Photo of Ewa Bryl

    Ewa Bryl

    • Gdański Uniwersytet Medyczny Wydział Lekarski, Katedra Fizjopatologii.
  • Photo of Adam Buciński

    Adam Buciński

    • Uniwersytet Mikołaja Kopernika, Collegium Medicum Wydział Farmaceutyczny

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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
FITOTERAPIA no. 90, pages 199 - 208,
ISSN: 0367-326X
Language:
English
Publication year:
2013
Bibliographic description:
Kokotkiewicz A., Łuczkiewicz M., Pawłowska J., Łuczkiewicz P., Sowiński P., Witkowski J., Bryl E., Buciński A.: Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis// FITOTERAPIA. -Vol. 90, (2013), s.199-208
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.fitote.2013.07.020
Verified by:
Gdańsk University of Technology

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