Poloxamer: A versatile tri-block copolymer for biomedical applications - Publication - Bridge of Knowledge

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Poloxamer: A versatile tri-block copolymer for biomedical applications

Abstract

Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers containing central hydrophobic chains of poly(propylene oxide) sandwiched between two hydrophilic chains of poly(ethylene oxide). Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials promising candidates for biomedical application such as tissue engineering and drug delivery. The microstructure, bioactivity, and mechanical properties of poloxamers can be tailored to mimic the behavior of various types of tissues. Moreover, their amphiphilic nature and the potential to self-assemble into the micelles make them promising drug carriers with the ability to improve the drug availability to make cancer cells more vulnerable to drugs. Poloxamers are also used for the modification of hydrophobic tissue-engineered constructs. This article collects the recent advances in design and application of poloxamer-based biomaterials in tissue engineering, drug/gene delivery, theranostic devices, and bioinks for 3D printing.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Acta Biomaterialia no. 110, pages 37 - 67,
ISSN: 1742-7061
Language:
English
Publication year:
2020
Bibliographic description:
Zarrintaj P., Ramsey J., Samadi A., Atoufi Z., Yazdi M., Ganjali M., Amirabad L., Zangene E., Farokhi M., Formela K., Saeb M., Mozafari M., Sabu T.: Poloxamer: A versatile tri-block copolymer for biomedical applications// Acta Biomaterialia -Vol. 110, (2020), s.37-67
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.actbio.2020.04.028
Verified by:
Gdańsk University of Technology

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