Sequence-dependent structural properties of B-DNA: what have we learned in 40 years? - Publication - Bridge of Knowledge

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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?

Abstract

The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA to recognize ligands and consequently on its functionality. In this sense, the knowledge obtained from the sequence-dependent structural properties of B-DNA has always been thought crucial to rationalize how ligands and, most notably, proteins recognize B-DNA and modulate its activity, i.e. the structural basis of gene regulation. Honouring the anniversary of the first high-resolution X-ray structure of a B-DNA molecule, in this contribution, we present the most important discoveries of the last 40 years on the sequence-dependent structural and dynamical properties of B-DNA, from the early beginnings to the current frontiers in the field.

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DOI:
Digital Object Identifier (open in new tab) 10.1007/s12551-021-00893-8
License
Copyright (2021 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature)

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Biophysical Reviews no. 13, pages 995 - 1005,
ISSN: 1867-2450
Language:
English
Publication year:
2021
Bibliographic description:
Da Rosa G., Grille L., Calzada V., Ahmad K., Arcon J. P., Battistini F., Bayarri G., Bishop T., Carloni P., Cheatham Iii T., Collepardo-Guevara R., Czub J., Espinosa J. R., Galindo-Murillo R., Harris S. A., Hospital A., Laughton C., Maddocks J. H., Noy A., Orozco M., Pasi M., Pérez A., Petkevičiūtė-Gerlach D., Sharma R., Sun R., Dans P. D.: Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?// Biophysical Reviews -Vol. 13,iss. 6 (2021), s.995-1005
DOI:
Digital Object Identifier (open in new tab) 10.1007/s12551-021-00893-8
Verified by:
Gdańsk University of Technology

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