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Abstract
As a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR), establishes its significance in cancer cells. Disrupting these defence mechanisms of shelterins, especially in cancer cells, renders telomeres vulnerable, potentially leading to genomic instability and hindering cancer cell survival. In this review, we outline recent approaches exploring shelterins as potential anticancer targets, highlighting the prospect of developing selective molecules to exploit telomere vulnerabilities toward new innovative cancer treatments.
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Authors (4)
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Wioletta Brankiewicz-Kopcinska dr
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
DRUG DISCOVERY TODAY
no. 29,
ISSN: 1359-6446 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Brankiewicz-Kopcinska W., Kallingal A., Krzemieniecki R., Bagiński M.: Targeting shelterin proteins for cancer therapy.// DRUG DISCOVERY TODAY -,iss. 29/8 (2024), s.1-15
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.drudis.2024.104056
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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