The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections - Publication - Bridge of Knowledge

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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections

Abstract

Scutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-
tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
diseases, including vaginal infections. In this study, six binary mixtures of chitosan with stable
S. baicalensis radix lyophilized extract were obtained and identified by spectral (ATR-FTIR, XRPD)
and thermal (TG and DSC) methods. The changes in dissolution rates of active compounds and
the significant increase in the biological properties towards metal chelating activity were observed,
as well as the inhibition of hyaluronic acid degradation after mixing plant extract with chitosan.
Moreover, the combination of S. baicalensis radix lyophilized extract with a carrier allowed us to obtain
the binary systems with a higher antifungal activity than the pure extract, which may be effective in
developing new strategies in the vaginal infections treatment, particularly vulvovaginal candidiasis.

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Authors (6)

  • Photo of dr n. farm. Justyna Chanaj-Kaczmarek

    Justyna Chanaj-Kaczmarek dr n. farm.

  • Photo of Natalia Rosiak

    Natalia Rosiak

  • Photo of Ewa Wender-Ozegowska

    Ewa Wender-Ozegowska

  • Photo of Judyta Cielecka-Piontek

    Judyta Cielecka-Piontek

  • Photo of Daria Szymanowska

    Daria Szymanowska

  • Photo of Marcin Rajewski

    Marcin Rajewski

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Category:
Magazine publication
Type:
Magazine publication
Published in:
Pharmaceutics no. 14, edition 4,
ISSN: 1999-4923
ISSN:
1999-4923
Publication year:
2022
DOI:
Digital Object Identifier (open in new tab) 10.3390/pharmaceutics14040740
Bibliography: test
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