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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections
Abstract
Scutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-
tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
diseases, including vaginal infections. In this study, six binary mixtures of chitosan with stable
S. baicalensis radix lyophilized extract were obtained and identified by spectral (ATR-FTIR, XRPD)
and thermal (TG and DSC) methods. The changes in dissolution rates of active compounds and
the significant increase in the biological properties towards metal chelating activity were observed,
as well as the inhibition of hyaluronic acid degradation after mixing plant extract with chitosan.
Moreover, the combination of S. baicalensis radix lyophilized extract with a carrier allowed us to obtain
the binary systems with a higher antifungal activity than the pure extract, which may be effective in
developing new strategies in the vaginal infections treatment, particularly vulvovaginal candidiasis.
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Authors (6)
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Natalia Rosiak
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Ewa Wender-Ozegowska
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Judyta Cielecka-Piontek
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Daria Szymanowska
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Marcin Rajewski
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Details
- Category:
- Magazine publication
- Type:
- Magazine publication
- Published in:
-
Pharmaceutics
no. 14,
edition 4,
ISSN: 1999-4923 - ISSN:
- 1999-4923
- Publication year:
- 2022
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/pharmaceutics14040740
- Verified by:
- No verification
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