Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea

Maciej Przybyłek; Dorota Ziółkowska; Mirosław Kobierski; Karina Mroczyńska; Piotr Cysewski

doi:10.1016/j.jcrysgro.2015.10.015

Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea

Abstract

The possibility of molecular complex formation in the solid state of urea with benzoic acid analogues was measured directly on the crystallite films deposited on the glass surface using powder X-ray diffractometry (PXRD). Obtained solid mixtures were also analyzed using Fourier transform infrared spectroscopy (FTIR). The simple droplet evaporation method was found to be efficient, robust, fast and cost-preserving approach for first stage cocrystal screening. Additionally, the application of orientation effect to cocrystal screening simplifies the analysis due to damping of majority of diffraction signals coming from coformers. During validation phase the proposed approach successfully reproduced both positive cases of cocrystallization (urea:salicylic acid and urea:4-hydroxy benzoic acid) as well as pairs of co-formers immiscible in the solid state (urea:benzoic acid and urea:acetylsalicylic acids). Based on validated approach new cocrystals of urea were identified in complexes with 3-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid and 3,5-dihydroxybenzoic acid. In all cases formation of multicomponent crystal phase was confirmed by the appearance of new reflexes on the diffraction patterns and FTIR absorption band shifts of O–H and N–H groups.

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Authors (5)

Maciej Przybyłek Dr
Dorota Ziółkowska
Mirosław Kobierski
Karina Mroczyńska
Piotr Cysewski

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Category:: Magazine publication
Type:: Magazine publication
Published in:: JOURNAL OF CRYSTAL GROWTH no. 433, pages 128 - 138,
ISSN: 0022-0248
ISSN:: 0022-0248
Publication year:: 2016
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.jcrysgro.2015.10.015
Verified by:: No verification