Search results for: REMYELINATION

• Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model

  Publication

  • K. Konieczna-Wolska
  • F. Caratis
  • M. Opiełka
  • K. Biernacki
  • K. Urbanowicz
  • J. Klimaszewska
  • P. Pobiarzyn
  • O. Krajewski
  • S. Demkowicz
  • R. T. Smoleński... and 3 others

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2024

  Research indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...

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• Natural fish oil improves the differentiation and maturation of oligodendrocyte precursor cells to oligodendrocytes in vitro after interaction with the blood–brain barrier

  Publication

  • P. Piatek
  • N. Lewkowicz
  • S. Michlewska
  • M. Wieczorek
  • R. Bonikowski
  • K. Parchem
  • P. Lewkowicz
  • M. Namiecinska

  - Frontiers in Immunology - Year 2022

  The blood–brain barrier (BBB) tightly controls the microenvironment of the central nervous system (CNS) to allow neurons to function properly. Additionally, emerging studies point to the beneficial effect of natural oils affecting a wide variety of physiological and pathological processes in the human body. In this study, using an in vitro model of the BBB, we tested the influence of natural fish oil mixture (FOM) vs. borage oil...

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