Search results for: WIEŚ
-
Photophysical properties of 3-[2-(N-phenylcarbazolyl)benzoxazol-5-yl]alanine derivatives – experimental and theoretical studies
Publication -
Investigation of the Membrane Localization and Interaction of Selected Flavonoids by NMR and FTIR Spectroscopy
Publication -
Polar localization of new flavonoids from aerial parts of Scleranthus perennis and Hottonia palustris and their modulatory action on lipid membranes properties
Publication -
Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
Publication -
The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA
PublicationMatrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide-DOX, the product of the MMPs' cleavage of carrier-linked DOX, into dsDNA was investigated using stationary and time-resolved fluorescence spectroscopy, UV-Vis...
-
A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia
Publication -
Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells
Publication -
Ontology groups representing angiogenesis and blood vessels development are highly up-regulated during porcine oviductal epithelial cells long-term real-time proliferation – a primary cell culture approach
Publication -
Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research
Publication -
Selected molecular and physiological aspects of mammalian ovarian granulosa cells in primary culture
Publication -
Cyclic Dipeptides as Building Units of Nano- and Microdevices: Synthesis, Properties, and Structural Studies
Publication -
Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
Publication -
Genetic diversity of Legionella pcs and pmtA genes and the effect of utilization of choline by Legionella spp. on induction of proinflammatory cytokines
Publication -
Up-regulation of ferritin ubiquitination in skeletal muscle of transgenic rats bearing the G93A hmSOD1 gene mutation
Publication -
Piroxicam derivatives THz classification
Publication -
Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic
PublicationAmphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we present detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based...
-
Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function
PublicationAmphotericin B (AmB), one of the most powerful but also toxic drugs used to treat systemic mycoses, is believed to selectively permeabilize fungal cell membranes to ions in a sterol-dependent manner. Unfortunately, the structure of the biologically active AmB channels has long eluded researchers, obstructing the design of safer alternatives. Here, we investigate the structural and thermodynamic aspects of channel formation, stability,...
-
Elektronika i elektrotechnika, W/L, IMM, st.I, 2023/24
e-Learning Courses -
Expression Profile of Genes Regulating Steroid Biosynthesis and Metabolism in Human Ovarian Granulosa Cells—A Primary Culture Approach
Publication -
Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
PublicationAmphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...
-
Pharmacological treatment of a depressive episode and recurrent depressive disorder – guidelines of the Polish Psychiatric Association and the National Consultant for Adult Psychiatry
Publication -
New Molecular Markers Involved in Regulation of Ovarian Granulosa Cell Morphogenesis, Development and Differentiation during Short-Term Primary In Vitro Culture—Transcriptomic and Histochemical Study Based on Ovaries and Individual Separated Follicles
Publication -
Identification and characterization of Staphylococcus spp. and their susceptibility to insect apolipophorin III
Publication -
Structural and luminescence investigation of GeO2-PbO-Bi2O3-SrF2 glasses doped with Eu3+, Tb3+ and Tm3+ ions
PublicationThe GeO2-PbO-Bi2O3-SrF2 (GePbBiSr) glass systems doped with Eu3 +, Tb3 +, Tm3 + and triply-doped with Eu3 +/Tb3 +/Tm3 + ions were successfully synthesized. Their structural and luminescent properties have been investigated with various techniques. Obtained results indicate that these glass systems are suitable materials for the RE3 + ions hosts. RE3 + ions can be excited by single UV light wavelength (355/378/395 nm) and simultaneously...
-
Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study
PublicationIn the early stages of drug discovery, beyond the biological activity screening, determining the physicochemical properties that affect the distribution of molecules in the human body is an essential step. Plasma protein binding (PPB) is one of the most important investigated endpoints. Nevertheless, the methodology for measuring %PPB is significantly less popular and standardized than other physicochemical properties, like lipophilicity....
-
The Teutonic crusade in Prussia: reconstruction of a medieval fortified settlement complex at Unisław
Publication -
A review on application of artificial neural network (ANN) for performance and emission characteristics of diesel engine fueled with biodiesel-based fuels
PublicationBiodiesel has been emerging as a potential and promising biofuel for the strategy of reducing toxic emissions and improving engine performance. Computational methods aiming to offer numerical solutions were inevitable as a study methodology which was sometimes considered the only practical method. Artificial neural networks (ANN) were data-processing systems, which were used to tackle many issues in engineering and science, especially...
-
Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells
Publication -
Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
Publication -
Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?
Publication -
Expression of integrins and GDF9 mRNAs is associated with ovarian follicle size and donor puberty status in pigs
Publication -
Morphogenesis-related gene-expression profile in porcine oocytes before and after in vitro maturation
Publication -
“Cell Migration” Is the Ontology Group Differentially Expressed in Porcine Oocytes Before and After In Vitro Maturation: A Microarray Approach
Publication -
Genes of cellular components of morphogenesis in porcine oocytes before and after IVM
Publication -
Influence of Estradiol-17beta on Progesterone and Estrogen Receptor mRNA Expression in Porcine Follicular Granulosa Cells during Short-Term, In Vitro Real-Time Cell Proliferation
Publication -
‘Heart development and morphogenesis’ is a novel pathway for human ovarian granulosa cell differentiation during long‑term in�vitro cultivation‑a microarray approach
Publication -
SCORE model underestimates cardiovascular risk in hypertensive patients: Results of the Polish Hypertension Registry
Publication -
Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublicationAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
-
“Bone Development” Is an Ontology Group Upregulated in Porcine Oocytes Before In Vitro Maturation: A Microarray Approach
Publication -
Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM – a microarray approach
Publication -
Effect of Drip Fertigation with Nitrogen on Yield and Nutritive Value of Melon Cultivated on a Very Light Soil
Publication -
Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatography-fluorescence detection
Publication -
Multivariate assessment of anticancer oleanane triterpenoids lipophilicity
Publication -
Genes Involved in the Processes of Cell Proliferation, Migration, Adhesion, and Tissue Development as New Potential Markers of Porcine Granulosa Cellular Processes In Vitro: A Microarray Approach
Publication -
Multisensor System for the Protection of Critical Infrastructure of Seaport
PublicationThere are many separated infrastructural objects within a harbor area that may be considered “critical”, such as gas and oil terminals or anchored naval vessels. Those objects require special protection, including security systems capable of monitoring both surface and underwater areas, because an intrusion into the protected area may be attempted using small surface vehicles (boats, kayaks, rafts, floating devices with weapons...
-
Molecular organization of antifungal antibiotic amphotericin B in lipid monolayers studied by means of Fluorescence Lifetime Imaging Microscopy
Publication -
The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III
Publication -
The differentiation and transdifferentiation of epithelial cells in vitro – is it a new strategy in regenerative biomedicine?
Publication -
Amino acids metabolism and degradation is regulated during porcine oviductal epithelial cells (OECs) primary culture in vitro – a signaling pathways activation approach
Publication -
Response of Chosen American Asparagus officinalis L. Cultivars to Drip Irrigation on the Sandy Soil in Central Europe: Growth, Yield, and Water Productivity
Publication