Search results for: C-MYC

• Amplification of c-myc gene and overexpression of c-Myc protein in breast cancer and adjacent non-neoplastic tissue

  Publication

  • P. Chrzan
  • J. Skokowski
  • A. Karmolinski
  • T. Pawelczyk

  - CLINICAL BIOCHEMISTRY - Year 2001

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• c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells

  Publication

  • A. Kurdyn
  • M. Pawłowska
  • E. Paluszkiewicz
  • M. Cichorek
  • E. Augustin

  - Pharmacological Reports - Year 2024

  Background Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh leading cause of cancer-related death worldwide. PC is characterized by rapid progression and resistance to conventional treatments. Mutations in KRAS, CDKN2A, TP53, SMAD4/DPC4, and MYC are major genetic alterations associated with poor treatment outcomes in patients with PC. Therefore, optimizing PC therapy is a tremendous challenge. Unsymmetrical...

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• c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells

  Publication

  • M. Pawłowska
  • J. Kulesza
  • E. Augustin

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2022

  Unsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...

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• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028005751]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028004541]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Spectroscopic studies on physicochemical properties of selected unsymmetrical bisacridine derivatives and NMR analysis of their interactions with the model sequence Pu22 aided by molecular dynamics

  Publication

  • M. Kosno

  - Year 2024

  In recent years, new promising acridine derivatives have appeared, belonging to the unsymmetrical bisacridines (UAs) family with high anticancer activity. Both their physicochemical properties and their mechanism of action at the molecular level have not been thoroughly analyzed so far. Four derivatives were selected for the study, termed as: C-2028, C-2041, C-2045 and C-2053. The first aim of this work was to determine the protonation...

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• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006171]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028004431]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028005611]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028001151]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028002671]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003681]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [704034723256111]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800551]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028008421]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800381]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003381]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003631]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028007521]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006841]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006081]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [50407300280011]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800191]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028007661]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006181]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028003571]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028008041]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028001981]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [7040247104948991]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028007291]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028004731]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028009161]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028002271]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028006011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028009891]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [504073002800431]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements - Male, 57 - Tissue image [5040730028005641]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Burkitt's tumour - Female, 6 - Tissue image [10060730015614021]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TONSIL tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Burkitt's tumour - Female, 6 - Tissue image [10060730015616131]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TONSIL tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Plasmablastic lymphoma - Female, 62 - Tissue image [6110730021433081]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.

• Burkitt lymphoma, NOS - Female, 12 - Tissue image [5190730046642261]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TONSIL tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• B lymphoblastic leukemia/lymphoma, NOS - Male, 26 - Tissue image [5150730018708241]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, NOS - Male, 49 - Tissue image [6120730031829291]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TESTIS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Burkitt lymphoma, NOS - Female, 19 - Tissue image [5190730046648911]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TONSIL tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mantle cell lymphoma - Male, 67 - Tissue image [5160730021344731]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of TONSIL tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• B-cell lymphoma, NOS - Unknown, 76 - Tissue image [3280730025612901]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of NASAL CAVITY AND MIDDLE EAR tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• EBV positive diffuse large B-cell lymphoma - Female, 70 - Tissue image [5190730046654301]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• EBV positive diffuse large B-cell lymphoma - Female, 70 - Tissue image [7040247104957181]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Malignant lymphoma, large B-cell, diffuse, NOS - Male, 55 - Tissue image [5190730046645881]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of PALATE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, NOS - Female, 56 - Tissue image [5020730020706461]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.