Search results for: GLMZ

• Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase

  Publication

  • M. Khan
  • Y. Gopel
  • S. Milewski
  • B. Gorke

  - Frontiers in Microbiology - Year 2016

  Formation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...

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• Regulated Control of the Assembly and Diversity of LPS by Noncoding sRNAs

  Publication

  • G. Klein-Raina
  • S. Raina

  - JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY - Year 2015

  The outer membrane (OM) of Gram-negative bacteria is asymmetric due to the presence of lipopolysaccharide (LPS) facing the outer leaflet of the OM and phospholipids facing the periplasmic side. LPS is essential for bacterial viability, since it provides a permeability barrier and is a major virulence determinant in pathogenic bacteria. In Escherichia coli, several steps of LPS biosynthesis and assembly are regulated by the RpoE...

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