Search results for: OCTAARGININE

• The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative

  Publication

  • K. Rząd
  • E. Paluszkiewicz
  • D. Neubauer
  • M. Olszewski
  • K. Kozłowska-Tylingo
  • W. Kamysz
  • I. Gabriel

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Acridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...

  Full text available to download

• Killing kinetics analysis of C-1311 derivative with octaarginine (Compound 1-R8) against Candida albicans

  Open Research Data

  open access

  • K. Rząd
  • D. Neubauer
  • I. Gabriel
  • E. Paluszkiewicz
  • K. Kozłowska-Tylingo
  • W. Kamysz

  - series: C-1305, C-1311

  The datasets contain the results of killing kinetics analysis of imidazoacridinone derivative and fluconazole against C. albicans ATCC 10231. The suspensions of Candida albicans ATCC 10231 cells (500 µL) in RPMI 1640 at cell density of 104 cells /mL were added to 500 µL of RPMI 1640 medium with various concentrations of the compounds, corresponding...