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Search results for: lipopeptide
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Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys–NH2 and an N-terminal Peptide of Human Lactoferricin on Biological Activity
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Lipopeptides - synthesis and their properties
PublicationPrzedstawiono syntezę nowych peptydów zawierających Hyp, Met, Gly podstawionych w miejscu histydyny tripeptydu o sekwencji Gly-His-Lys oraz ich odpowiednie modyfikacje na N- i C-końcach. Syntezę zaprojektowanych analogów prowadzono na fazie stałej z zastosowaniem procedury Fmoc. Po otrzymaniu zaplanowanego łańcucha peptydowego metodą karbodiimidową (z zastosowaniem DIC oraz HOBt), przystąpiono do wprowadzania na N-koniec glicyny...
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Lipopeptides - synthesis and their properties
PublicationZaprezentowano syntezę nowych pochodnych tripeptydu Gly-Hyp-Lys o potencjalnie lepszych właściwościach lipofilowych. Modyfikacje polegały na acylowaniu N-końca glicyny kwasami tłuszczowymi (np. palmitynowym i stearynowym). Syntezę lipopeptydów zawierających fragment Gly-X-Y (gdzie: X= Met,Hyp,Hyp-Met,Gly-Hyp; Y=Lys,D-Lys) przeprowadzono na fazie stałej z zastosowaniem procedury Fmoc. Do wydłużanie łańcucha peptydowego zastosowano...
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Novel dendrimeric lipopeptides with antifungal activity
PublicationZaprojektowano, zsyntezowano i scharakteryzowano serię nowych kationowych lipopeptydów zawierających rozgałęziony, amfifilowy polarny rdzeń strukturalny pochodzący od dendronu (Lys)(Lys)(Lys) oraz łańcuchy C8 i C12 na C-końcu. Otrzymane zwiazki wykazywały aktywność przeciwdrobnoustrojową, w tym szczególnie przeciwgrzybową wobec drożdżaków z rodzaju Candida. Najwyższą aktywność, selektywną wobec drobnoustrojów grzybowych, wykazywały...
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In vitro evaluation of novel lipopeptides with potential therapeutic application
PublicationThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
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Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials
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Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media
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Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity
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Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity
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Effect of self-assembly on antimicrobial activity of double-chain short cationic lipopeptides
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublicationShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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Characterization of antimicrobial and hemolytic properties of short synthetic cationic lipopeptides based on QSAR/QSTR approach
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Self-assembly and interactions of short antimicrobial cationic lipopeptides with membrane lipids: ITC, FTIR and molecular dynamics studies
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Ultrashort Cationic Lipopeptides–Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis
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Synthetic lipopeptides as potential topical therapeutics in wound and skin care: in vitro studies of permeation and skin cells behaviour
PublicationSeveral Gly-His-Lys analogues were obtained to investigate their antimicrobial properties. Three lipophilic analogues with the structure numbering 1b, 2b, 4b, exhibit significant effect against bacteria and were selected for in vitro evaluation of skin cells behaviour. In the present studies, an in vitro model of wound repair, proliferative cell staining, and tracking of living cells were used. Cell proliferation and cell migration,...
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In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections
PublicationWe presented in vitro studies of antimicrobial activity of Gly-His-Lys conjugates that are important point in preliminary biological evaluation of their potential application in skin and tissue therapy. The novel compounds include the conjugation of fatty acids with a modification of the amino acid sequence in the primary structure of Gly-His-Lys.