Search results for: CHONDROITIN SULFATE

• Hyaluronan-Chondroitin Sulfate Anomalous Crosslinking Due to Temperature Changes

  Publication

  • T. Andrysiak
  • P. Bełdowski
  • J. Siódmiak
  • P. Weber
  • D. Ledziński

  - Polymers - Year 2018

  Glycosaminoglycans are a wide class of biopolymers showing great lubricating properties due to their structure and high affinity to water. Two of them, hyaluronic acid and chondroitin sulfate, play an important role in articular cartilage lubrication. In this work, we present results of the all-atom molecular dynamics simulations of both molecules placed in water-based solution. To mimic changes of the physiological conditions,...

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• APPLIED SURFACE SCIENCE

  Journals

  ISSN: 0169-4332 , eISSN: 1873-5584

• SURFACE & COATINGS TECHNOLOGY

  Journals

  ISSN: 0257-8972

• Surface Innovations

  Journals

  ISSN: 2050-6252 , eISSN: 2050-6260

• Ocular Surface

  Journals

  ISSN: 1542-0124 , eISSN: 1937-5913

• Surface Technology

  Journals

  eISSN: 1001-3660

• Effect of Ion and Binding Site on the Conformation of Chosen Glycosaminoglycans at the Albumin Surface

  Publication

  • P. Sionkowski
  • P. Bełdowski
  • N. Kruszewska
  • P. Weber
  • B. Marciniak
  • K. Domino

  - ENTROPY - Year 2022

  Albumin is one of the major components of synovial fluid. Due to its negative surface charge, it plays an essential role in many physiological processes, including the ability to form molecular complexes. In addition, glycosaminoglycans such as hyaluronic acid and chondroitin sulfate are crucial components of synovial fluid involved in the boundary lubrication regime. This study presents the influence of Na+, Mg2+ and Ca2+ ions...

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• Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors

  Publication

  • S. Demkowicz
  • M. Daśko
  • W. Kozak
  • K. Krawczyk
  • D. Witt
  • M. Masłyk
  • K. Kubiński
  • J. Rachoń

  - Chemical Biology & Drug Design - Year 2016

  In the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...

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• SURFACE SCIENCE

  Journals

  ISSN: 0039-6028 , eISSN: 1879-2758

• China Surface Engineering

  Journals

  ISSN: 1007-9289