Search results for: MOLECULAR UMBRELLAS

• Molecular Umbrella as A Nanocarrier for Antifungals

  Publication

  • A. S. Skwarecki
  • D. Martynow
  • M. J. Milewska
  • S. Milewski

  - MOLECULES - Year 2021

  A molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...

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• Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals

  Publication

  • A. S. Skwarecki
  • K. Skarbek
  • D. Martynow
  • M. Serocki
  • I. Bylińska
  • M. J. Milewska
  • S. Milewski

  - BIOCONJUGATE CHEMISTRY - Year 2018

  Antifungal polyene macrolide antibiotics Amphotericin B (AmB) and Nystatin (NYS) were conjugated through the ω-amino acid linkers with diwalled “molecular umbrellas” composed of spermidine-linked deoxycholic or cholic acids. The presence of “umbrella” substituents modulated biological properties of the antibiotics, especially their selective toxicity. Some of the AmB-umbrella conjugates demonstrated antifungal in vitro activity...

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• MOLECULES

  Journals

  ISSN: 1420-3049

• Analytical data on molecular umbrella: cispentacin and molecular umbrella: fluorescent probe conjugates

  Open Research Data

  open access

  • S. Milewski
  • A. Skwarecki
  • M. Milewska

  Analytical data (NMR, MS, FTIR) for nine conjugates of molecular umbrella with cispentacin, Lys(Mca) or Nap-NH2. The conjugates have been rationally designed as potential antifungal agents. 1H NMR and 13C NMR spectra were obtained at 500 MHz Varian Unity Plus spectrometer and the deuterated solvents were used as internal locks. High-resolution mass...

• Paweł Możejko dr hab.

  People

  Zakład Fizyki Zderzeń Elektronowych, Instytut Fizyki i Informatyki Stosowanej

• MOLECULAR PHYSICS

  Journals

  ISSN: 0026-8976 , eISSN: 1362-3028

• JOURNAL OF MOLECULAR STRUCTURE

  Journals

  ISSN: 0022-2860 , eISSN: 1872-8014

• Molecular Dynamics Study of the Internal Water Molecules in Vasopressin and Oxytocin Receptors

  Publication

  • M. Slusarz
  • R. Slusarz
  • J. Ciarkowski
  • R. Ślusarz

  - Protein & Peptide Letters - Year 2009

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• Planar chiral dianthranilide and dithiodianthranilide molecules: optical resolution, chiroptical spectra, and molecular self-assembly.

  Publication

  • T. Olszewska
  • M. Gdaniec
  • T. Połoński

  - Year 2004

  Chiralny planarnie diantranilid został rozdzielony na enancjomery przy użyciu chlorku (-)-(1S,4R)-kamfanoilu. Konfigurację absolutną (S)-enancjomeru ustalono na podstawie analizy rentgenograficznej monokryształu jego N,N'-dikamfoilopochodnej. Natomiast rozdział ditiodiantranilidu na enancjomery przeprowadzono poprzez tworzenie związków inkluzyjnych z (R,R)-1,2-diaminocykloheksanem. Otrzymanemu w ten sposób enancjomerowi przypisano...

• Molecular Physics Reports

  Journals

  ISSN: 1505-1250