Search results for: P53 PROTEIN

• ANALYSIS OF THE p53 PROTEIN GENE EXPRESSION MODEL

  Publication

  • A. Bartłomiejczyk
  • M. Bodnar
  • M. Piotrowska

  - Year 2015

  We study the asymptotic behaviour of the solutions of the p53-Mdm2 model proposed by Monk (2003). The p53 gene is crucial for cellular inhibition of the angiogenesis process, while Mdm2 is a negative regulator of the p53 tumor-suppressor. We investigate the stability of the positive steady state and perform some numerical experiments.

• Targeting of p53 and its homolog p73 by protoporphyrin IX

  Publication

  • A. Sznarkowska
  • K. Maleńczyk
  • L. Kadziński
  • K. Bielawski
  • B. Banecki
  • J. Zawacka-Pankau
  • K. P. Bielawski

  - FEBS LETTERS - Year 2011

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• Mathematical analysis of a generalised p53-Mdm2 protein gene expression model

  Publication

  • M. Piotrowska
  • A. Bartłomiejczyk
  • M. Bodnar

  - APPLIED MATHEMATICS AND COMPUTATION - Year 2018

  We propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...

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• PROTEIN EXPRESSION AND PURIFICATION

  Journals

  ISSN: 1046-5928 , eISSN: 1096-0279

• Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

  Publication

  • M. Szybka
  • I. Zawlik
  • D. Kulczycka
  • E. Golanska
  • E. Jesien
  • D. Kupnicka
  • R. Stawski
  • S. Piaskowski
  • E. Bieniek
  • M. Zakrzewska... and 3 others

  - BRITISH JOURNAL OF CANCER - Year 2008

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• Function and Frustration of Multi-Drug ABC Exporter Protein and Design of Model Proteins for Drug Delivery Using Protein Hydration Thermodynamics

  Publication

  • D. Urry
  • K. Urry
  • W. Szaflarski
  • M. Nowicki
  • M. Zabel

  - CURRENT PHARMACEUTICAL DESIGN - Year 2009

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• The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation

  Publication

  • A. Skwarska
  • S. Ramachandran
  • G. Dobrynin
  • K. B. Leszczynska
  • E. M. Hammond

  - Oncotarget - Year 2017

  C-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...

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• Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery

  Publication

  • D. Urry
  • K. Urry
  • W. Szaflarski
  • M. Nowicki

  - ADVANCED DRUG DELIVERY REVIEWS - Year 2010

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• Protein & Cell

  Journals

  ISSN: 1674-800X , eISSN: 1674-8018

• PROTEIN JOURNAL

  Journals

  ISSN: 1572-3887 , eISSN: 1573-4943