Search
Didn't find any results in this catalog!
But we have some results in other catalogs.displaying 1000 best results Help
Search results for: reverse transcriptase
-
Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds
PublicationReverse transcriptase (RT) inhibitors are currently used to treat human immunodeficiency virus (HIV)-1 infections. In this work, novel triethylamine derivatives were designed and studied by rigid and flexible docking and molecular dynamics (MD) approaches. An apo form of HIV-1 RT was also studied by MD simulation to analyze comparative response of protein in ligand-bound and ligand-unbound forms. Among newly designed HIV-1 RT inhibitors,...
-
Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
Publication -
Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
-
Rivers Try Harder. Reversed “Differential Erosion” as Geological Control of Flood in the Large Fluvial Systems in Poland
Publication -
A contribution to the moss and liverwort flora of the Reberce Nature Reserve at the Przemyśl Foothills (Western Carpathians, Poland)
Publication -
Surface shape reverse engineering with nurbs
PublicationW artykule zaprezentowano algorytm, który interpoluje prostokątną tablice punktów w przestrzeni trójwymiarowej przy pomocy powierzchni NURBS. Algorytm oblicza parametry powierzchni NURBS tak, aby jak najwierniej oddać kształt opisany przez punkty. Do interpolacji punktów wybrano powierzchnię NURBS, jako najbardziej uniwersalny i najczęściej używany w programach CAD rodzaj powierzchni. Interpolowane punkty mogą pochodzić zarówno...
-
Analytical design method of reverse curves
PublicationThe paper deals with a new approach relating to the design of the region of railway track direction alteration adapted to Mobile Satellite Measurements technique. The method may be particularly useful in situations when both the straights of the route directions cannot be connected in an elementary way using a circular arc with transition curves; this also refers to the application of a compound curve. Thus the only solution becomes...
-
The methylome and transcriptome of fetal skin: implications for scarless healing
PublicationAim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated...
-
Hybrid Obfuscation Technique for Reverse Engineering Problems
Publication -
RSN reverse converter based on core function
Publicationzaprezentowano nową architekturę konwertera z systemu resztowego do systemu binarnego opartego na funkcji jądra dla modułów 5-bitowego. Zastosowano niekrytyczną funkcję jądra.Obliczanie funkcji jądra jest realizowane przy użyciu chińskiego twierdzenia dla funkcji jądra (CRTCF). Założono także, że jeden z modułów jest potegą 2. Architektura ta umożliwia zmniejszenie złożoności sprzętowej o ok. 12.5% w porównaniu z innymi architekturami...