Search results for: THROMBIN

• Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

  Publication

  • W. Kotkowiak
  • J. Lisowiec-Wachnicka
  • J. Grynda
  • R. Kierzek
  • J. Wengel
  • A. Pasternak

  - Molecular Therapy-Nucleic Acids - Year 2018

  Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparallel G-quadruplex structure with a chair-like conformation. In this paper, we report on our investigations on the influence of certain...

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• Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation

  Publication

  • L. Drabik
  • P. Wołkow
  • A. Undas

  - THROMBOSIS RESEARCH - Year 2015

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• The New 3D Printed Left Atrial Appendage Closure with a Novel Holdfast Device: A Pre-Clinical Feasibility Animal Study

  Publication

  • M. Brzeziński
  • K. Bury
  • L. Dąbrowski
  • P. Holak
  • A. Sejda
  • M. Pawlak
  • D. Jagielak
  • Z. Adamiak
  • J. Rogowski

  - PLOS ONE - Year 2016

  Many patients undergoing cardiac surgery have risk factors for both atrial fibrillation and stroke. The left atrial appendage (LAA) is the primary site for thrombi formation. Therefore LAA occlusion devices should be tested for their ability to reduce future cerebral ischemic events in patients with high-risk of haemorrhage. The aim of this study was to evaluate the safety and feasibility of a novel left atrial appendage exclusion...

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• Novel method of expression and purification of hirudin based on pBAD TOPO, pTYB12 vectors and gene synthesis

  Publication

  • R. Kochanowski
  • R. Kotlowski
  • P. Szweda

  - PROTEIN EXPRESSION AND PURIFICATION - Year 2006

  W pracy przedstawiono nową, szybką i tanią metodę otrzymywania, ekspresji i oczyszczania białka hirudyny naturalnie izolowanego z ślinianek pijawki lekarskiej. Hirudyna pełni funkcje bezpośredniego inhibitora trombiny, głównego białka biorącego udział w tworzeniu skrzepów krwi. Właściwości te wykorzystywane są od wielu lat w klinice. Opracowana metoda pozwoliła uzyskać 17 mg/l hodowli E. coli białka o wysokiej czystości i aktywności...

• Abdominal Aortic Aneurysm segmentation from contrast-enhanced computed tomography angiography using deep convolutional networks

  Publication

  • T. Dziubich
  • P. Białas
  • Ł. Znaniecki
  • J. Halman
  • J. Brzeziński

  - Year 2020

  One of the most common imaging methods for diagnosing an abdominal aortic aneurysm, and an endoleak detection is computed tomography angiography. In this paper, we address the problem of aorta and thrombus semantic segmentation, what is a mandatory step to estimate aortic aneurysm diameter. Three end-to-end convolutional neural networks were trained and evaluated. Finally, we proposed an ensemble of deep neural networks with underlying...

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• Acute myocardial infarction - Male, 71 - Tissue image [12030630017642531]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of HEART, MEDIASTINUM, AND PLEURA tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Discordant ventriculoarterial connection - Male, 1 - Tissue image [3070630010186761]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Discordant ventriculoarterial connection - Male, 1 - Tissue image [3070630010187061]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Angiolipoma, NOS - Male, 41 - Tissue image [6140729599017011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Angiolipoma, NOS - Female, 58 - Tissue image [614072959901841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.