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Search results for: CELL HYPOXIA
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Cell Discovery
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Cell Regeneration
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Microbial Cell
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Biopolymers and Cell
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Vascular Cell
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Cell Stress
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Cell Genomics
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MOLECULAR CELL
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Hypatia: A Journal of Feminist Philosophy
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Expression of stem cell and mesenchymal markers in circulating tumor cells is associated with poor prognosis of early breast cancer patients
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The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
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The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients
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CELL BIOLOGY INTERNATIONAL
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HISTOCHEMISTRY AND CELL BIOLOGY
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Muscle Cell Morphogenesis, Structure, Development and Differentiation Processes Are Significantly Regulated during Human Ovarian Granulosa Cells In Vitro Cultivation
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Increased susceptibility of PARP-1 KO cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
PublicationTriazoloakrydon C-1305 jest nowym inhibitorem topoizomerazy II wykazującym wysoką aktywność przeciwnowotworową. W tej pracy badaliśmy działanie cytotoksyczne pochodnej C-1305 i jej analogu strukturalnego C-1533 wobec komórek fibroblastów mysich i dwóch mutantów, w których uszkodzono gen PARP-1. Jak wykazaliśmy, komórki z uszkodzonym genem PARP-1 są nadwrażliwe na działanie związku C-1305 w porównaniu z komórkami PARP-1 +/+ podczas...
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Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Cell Membrane Transport Mechanisms: Ion Channels and Electrical Properties of Cell Membranes
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Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle
PublicationTriazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...
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Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells
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Germ cell-like telomeric length homeostasis in nonseminomatous testicular germ cell tumors
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Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Phosphate exchange across the sediment-water interface under oxic and hypoxic/anoxic conditions in the southern Baltic Sea
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Benthic fluxes of oxygen and nutrients under the influence of macrobenthic fauna on the periphery of the intermittently hypoxic zone in the Baltic Sea
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CELL MOTILITY AND THE CYTOSKELETON
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CELL AND TISSUE BANKING
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CELL COMMUNICATION AND ADHESION
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CELL STRUCTURE AND FUNCTION
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BMC CELL BIOLOGY
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Cell Adhesion & Migration
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Cell Host & Microbe
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Cell Preservation Technology
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Cell Communication and Signaling
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Cell Chemical Biology
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Anatomy & Cell Biology
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Cell Health and Cytoskeleton
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BRAIN CELL BIOLOGY
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Stem Cell Reports
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PIGMENT CELL RESEARCH
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Stem Cell Investigation
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Journal of Cell Death
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Cell and Tissue Biology
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Methods in Cell Biology
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NATURE CELL BIOLOGY
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Cell and Organ Transplantology
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Cell Reports Medicine
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