Search
Search results for: MGLU RECEPTORS
-
Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis
PublicationThe Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M1, M4, and M5 receptors) and metabotropic glutamate (mGlu) receptors are important targets in the search for antipsychotic drugs with the potency to treat cognitive disabilities associated with...
-
Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors
Publication -
RECEPTORS & CHANNELS
Journals -
Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems
Publication -
Nuclear Receptor Signaling
Journals -
Molecular Docking-Based Study of Vasopressin Analogues Modified at Positions 2 and 3 with N-Methylphenylalanine: Influence on Receptor-Bound Conformations and Interactions with Vasopressin and Oxytocin Receptors
Publication -
Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: Molecular dynamics simulation of the agonist-bound state in the membrane–aqueous system
Publication -
Classical Receptions Journal
Journals -
Study of New Oxytocin Antagonist Barusiban (Fe200 440) Affinity Toward Human Oxytocin Receptor Versus Vasopressin V1a and V2 Receptors - Molecular Dynamics Simulation in POPC Bilayer
Publication -
Pyridylmethylsilanes as dicarboxyacid receptors: Experimental and theoretical study
Publication -
Estrogen Receptors in Cell Membranes: Regulation and Signaling
Publication -
Evidence for sex steroid receptors in feline brainstem
Publication -
Journal of Receptor Ligand and Channel Research
Journals -
Expression of hCG and GnRHs and Their Receptors in Endometrial Carcinoma and Hyperplasia
Publication -
new analogues of agmatine with higher activity to imidazoline receptors
PublicationOpracowano syntezę nowych pochodnych imidazoliny, będących kompilacją struktury agmatyny i imidazoliny w wyniku zaprojektowanej przez nas drogi syntezy. Kluczowymi substratami w syntezie były pochodne 1,2,4 -triaminobutanu, otrzymane z chronionego kwasu glutaminowego. Otrzymane nowe pochodne imidazoliny wykazywały zróżnicowane powinowactwo do receptorów imidazolinowych I1, I2 oraz do receptorów alfa -adrenergicznych.
-
Angiotensin receptor blockers and endpoint protection
Publication -
Vasopressin V2 receptor/bioligand interactions
Publication -
Quantitative chirality in the binding of androgens to their receptor
Publication -
Molecular Modeling of Interaction of the Vasopressin Analogs with Vasopressin and Oxytocin Receptors
Publication -
Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
Publication -
Estrogen receptors genes polymorphisms and age at menarche in idiopathic scoliosis
Publication -
QSPR analysis of some agonists and antagonists of α-adrenergic receptors
Publication -
Chromogenic amides of pyridine-2,6-dicarboxylic acid as anion receptors
PublicationThe synthesis of simple, chromogenic pyridine-2,6-dicarboxylic acid amides, derivates of isomeric nitroanilines and aminonitrophenols, and their ion binding properties are described. The ligands' response to ionic species was examined by naked eye and was studied with the use of UV-Vis spectroscopy in DMSO and its mixture with water. The effect of the localisation and the type of the substituents in aromatic rings were discussed....
-
Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB
PublicationThe olfactory bulbectomized (OBX) rat model is a well-established model of depression in which antidepressant drugs reverse deficits in the passive avoidance test 14 days after administration. Recently, the olfactory bulbectomized rat model has been proposed to be a model of Alzheimer’s disease (AD), and the available data indicate similarities between the changes that typically occur in AD and those observed in OBX animals. In...
-
Molecular Modeling of the Neurohypophyseal Receptor/Atosiban Complexes
Publication -
Estrogen receptor 2 polymorphism in idiopathic scoliosis
Publication -
Affinity of fentanyl and its derivatives for the σ1-receptor
Publication -
Selective detection of F- by chromogenic tetrazole receptor
PublicationA chromogenic anion host 4, containing two amide functionalities linked to azo dye and tetrazole rings was synthesized and its complexes with various anions were investigated. The results show that receptor 4 can recognize selectively biologically important F- ion. The binding affinity for F- was investigated by naked-eye colour change, UV-Vis and 1H NMR spectroscopy. Addition F- ion in CH3CN and DMSO to receptor 4 cause a colour...
-
Molecular Dynamics Study of the Internal Water Molecules in Vasopressin and Oxytocin Receptors
Publication -
Estrogen receptors 1 and 2 genotypes and age at menarche in idiopathic scoliosis
Publication -
Moving out of CF3‐Land: Synthesis, Receptor Affinity, and in silico Studies of NK1 Receptor Ligands Containing a Pentafluorosulfanyl (SF5) Group
Publication -
Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality
Publication -
Neurohypophyseal Receptors-Ligands: Where We Are After the Landmark Rhodopsin Structure Determination
Publication -
Molecular Dynamics of Complexes of Atosiban with Neurohypophyseal Receptors in the Fully Hydrated Phospholipid Bilayer
Publication -
Theoretical Study on Interactions of Bicyclic Vasopressin Analogues with Human Neurohypophyseal Hormone Receptors
Publication -
Synthesis of Fentanyl Triazole Derivatives and their Affinity for Mu-Opioid and Sigma-1 Receptors
Publication -
Estrogen Receptor 2 Gene Polymorphism in Idiopathic Scoliosis
Publication -
Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands
Publication -
Targeting melanocortin receptor type 1 with small peptides
Publication -
Vitamin D receptor(s): In the nucleus but also at membranes?
Publication -
Trend research of vitamin D receptor: Bibliometric analysis
Publication -
Gαi-derived peptide binds the µ-opioid receptor
Publication -
Molecular dynamics of fentanyl bound to μ-opioid receptor
Publication -
Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
-
New clicked full agonists of the estrogen receptor β
PublicationA click chemistry approach was used to synthesize a series of 1,4-diaryl-substituted 1,2,3-triazoles designed to behave as estrogen receptor (ER) ligands. We studied their affinities for both receptors α and β, their agonist activities in a cell-based luciferase reporter assay and their effect on the proliferation of the hormone-dependent MCF-7 cell line. We found two compounds (3a and 3c) that behave as selective full agonists...
-
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
Publication -
Tuning the sumanene receptor structure towards the development of potentiometric sensors
Publication -
Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
Publication -
The neuroprotective activity of new phenylalanine-based AMPA receptor antagonists
Publication -
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
Publication