Year 2014

• TBAF Promoted Formation of Symmetrical Trisulfides

  Publication

  • S. Lach
  • D. Witt

  - HETEROATOM CHEMISTRY - Year 2014

  We have developed a new method for the synthesis of functionalized symmetrical trisulfides based on (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorin-2-yl)disulfanyl derivatives prepared from readily available 5,5-dimethyl-2-sul-fanyl-2-thioxo-1,3,2-dioxaphosphorinane or bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl) disulfide. The symmetrical trisulfides can be obtained from aliphatic and aromatic thiols andL-cysteine derivatives...

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Year 2013

• An efficient and convenient synthesis of unsymmetrical disulfides from thioacetates

  Publication

  • S. Lach
  • S. Demkowicz
  • D. Witt

  - TETRAHEDRON LETTERS - Year 2013

  We have developed convenient methods for the synthesis of functionalized unsymmetrical dialkyl disulfides under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives 1 with functionalized alkyl thiolate anions, generated in situ from thioacetates2and sodium methoxide or butylamine. The developed method allows the preparation...

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• Efficient Synthesis of Functionalized Unsymmetrical Dialkyl Trisulfanes

  Publication

  • S. Lach
  • D. Witt

  - SYNLETT - Year 2013

  We have developed a convenient method for the synthesis of functionalized unsymmetrical dialkyl trisulfanes under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives with alkyl disulfanyl anions generated in situ from S-acetyl disulfanyl derivatives and sodium methoxide. The developed method allows for the preparation of...

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• Pochodne kwasu neopentylidenofosforoditiowego jako substraty do syntezy ugrupowania trisulfidowego

  Publication

  • S. Lach

  - Year 2013

  Badania przeprowadzone w Katedrze Chemii Organicznej Wydziału Chemicznego Politechniki Gdańskiej na przestrzeni ostatnich kilku lat, pokazały wszechstronność pochodnych kwasu neopentylidenofosforoditiowego [32] w syntezie symetrycznie i niesymetrycznie podstawionego ugrupowania disulfidowego. Wyniki powyższych badań doprowadziły do opracowania nowej strategii syntetycznej, umożliwiającej otrzymywanie...