dr inż. Julia Borzyszkowska-Bukowska
Zatrudnienie
- Adiunkt w Katedra Technologii Leków i Biochemii
Kontakt dla biznesu
- Lokalizacja
- Al. Zwycięstwa 27, 80-219 Gdańsk
- Telefon
- +48 58 348 62 62
- biznes@pg.edu.pl
Media społecznościowe
Kontakt
Adiunkt
- Miejsce pracy
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Budynek B Wydz. Chemii
pokój 1 otwiera się w nowej karcie - Telefon
- +48 58 347 20 79
- julia.borzyszkowska-bukowska@pg.edu.pl
Wybrane publikacje
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Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis
Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nude mice. At the cellular level, these compounds affected 3D cancer spheroid growth and their cellular uptake was selectively modulated by quantum dots. UAs were shown to undergo metabolic...
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The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)
Herein, the stereostructure of the aromatic heptaene macrolide (AHM) antifungal antibiotic candicidin A3 (syn. ascosin A3, levorin A3) has been established upon the 2D NMR studies, consisting of DQF-COSY, TOCSY, ROESY, HSQC and HMBC experiments, as well as upon extensive molecular dynamics simulations. The geometry of the heptaenic chromophore was defined as: (22E, 24E, 26Z, 28Z, 30E, 32E, 34E). The previously unreported absolute...
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C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC) 2 :C-1311 complex
Imidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-derived stereostructure of d(GAGGCCTC)2:C-1311 complex was reported. The ligand was found locating itself between A and G moieties, forming...
Uzyskane stopnie/tytuły naukowe
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2022-07-08
Nadanie stopnia naukowego
dr inż. Nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych)
wyświetlono 998 razy